The Glenn Research Center (GRC) Telescience Support Center (TSC) is a NASA telescience ground facility that provides the capability to execute ground support operations of on-orbit International Space Station (ISS) and Space Shuttle payloads. This capability is provided with the coordination with the Marshall Space Flight Center (MSFC) Huntsville Operations Support Center (HOSC), the Johnson Space Center (JSC) Mission Control Center in Houston (MCC-H) and other remote ground control facilities. The concept of telescience is a result of NASA's vision to provide worldwide distributed ISS ground operations that will enable payload developers and scientists to control and monitor their on-board payloads from any location -- not necessarily a NASA site. This concept enhances the quality of scientific and technological data while decreasing operation costs of long-term support activities by providing ground operation services to a Principal Investigator and Engineering Team at their home site. The TSC acts as a hub in which users can either locate their operations staff within the walls of the TSC or request the TSC operation capabilities be extended to a location more convenient such as a university.