iss058e000975 (12/26/2018) --- A view of the Organs-On-Chips as a Platform for Studying Effects of Microgravity on Human Physiology investigation taken onboard the International Space Station (ISS). Organs-On-Chips as a Platform for Studying Effects of Microgravity on Human Physiology analyzes the effect of microgravity and other space-related stressors on the brain blood barrier. It uses fully automated tissue chip technology, a Brain-Chip, consisting of living neuronal and vascular endothelial cells in a micro-engineered environment. Results may provide insight into the relationship between inflammation and brain function and a better understanding of neurodegenerative diseases such as Alzheimer’s and Parkinson’s.