iPSC grown attached as a mat in 2D on Earth as the current state-of-the-art (left) vs. iPSC experimentally grown as spheres in suspension in 3D bioreactors on Earth in simulated microgravity conditions (right). This spaceflight experiment is hypothesizing to grow the cells in space to higher quality, faster, and/or higher numbers than in the simulated conditions on Earth. (Credit: BioServe)

jsc2025e007240 (2/18/2025) ---Induced pluripotent stem cells (iPSCs) grown attached as a mat in 2D on Earth as the current state-of-the-art (left) vs. iPSC experimentally grown as spheres in suspension in 3D bioreactors on Earth in simulated microgravity conditions (right). In-Space Production of Induced Pluripotent Stem Cells for Clinical Application (StemCellEX-IP1) investigation aims to use microgravity to expand and mass-produce high quality human iPSCs. Image courtesy of BioServe.

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