Spacelab Life Science -1 (SLS-1) was the first Spacelab mission dedicated solely to life sciences. The main purpose of the SLS-1 mission was to study the mechanisms, magnitudes, and time courses of certain physiological changes that occur during space flight, to investigate the consequences of the body's adaptation to microgravity and readjustment to Earth's gravity, and bring the benefits back home to Earth. The mission was designed to explore the responses of the heart, lungs, blood vessels, kidneys, and hormone-secreting glands to microgravity and related body fluid shifts; examine the causes of space motion sickness; and study changes in the muscles, bones, and cells. This photograph shows astronaut Rhea Seddon conducting an inflight study of the Cardiovascular Deconditioning experiment by breathing into the cardiovascular rebreathing unit. This experiment focused on the deconditioning of the heart and lungs and changes in cardiopulmonary function that occur upon return to Earth. By using noninvasive techniques of prolonged expiration and rebreathing, investigators can determine the amount of blood pumped out of the heart (cardiac output), the ease with which blood flows through all the vessels (total peripheral resistance), oxygen used and carbon dioxide released by the body, and lung function and volume changes. SLS-1 was launched aboard the Space Shuttle Orbiter Columbia (STS-40) on June 5, 1995.
View of Integrated Cardiovascular (ICV) Echo Ultrasound Scan,in the Columbus module. ICV aims to quantify the extent,time course and clinical significance of cardiac atrophy (decrease in the size of the heart muscle) in space. Photo was taken during Expedition 34.
S73-34180 (7 Aug. 1973) --- A medium close-up view of astronaut Jack R. Lousma, Skylab 3 pilot, in the Lower Body Negative Pressure Device (LBNPD), as astronaut Alan L. Bean, commander, works around the leg band area. This portion of the LBNPD MO-92 experiment was televised on Aug. 7, 1973. The LBNPD experiment is to provide information concerning the time course of cardiovascular adaptation during flight, and to provide in-flight data for predicting the degree of orthostatic intolerence and impairment of physical capacity to be expected upon returning to Earth environment. The bicycle ergometer is in the background, partially visible behind Bean. Photo credit: NASA
SL3-108-1278 (July-September 1973) --- Scientist-astronaut Owen K. Garriott, science pilot of the Skylab 3 mission, lies in the Lower Body Negative Pressure Device in the work and experiments area of the Orbital Workshop (OWS) crew quarters of the Skylab space station cluster in Earth orbit. This picture was taken with a hand-held 35mm Nikon camera. Astronauts Garriott, Alan L. Bean and Jack R. Lousma remained with the Skylab space station in orbit for 59 days conducting numerous medical, scientific and technological experiments. The LBNPD (MO92) Experiment is to provide information concerning the time course of cardiovascular adaptation during flight, and to provide in-flight data for predicting the degree of orthostatic intolerance and impairment of physical capacity to be expected upon return to Earth environment. The bicycle ergometer is in the right foreground. Photo credit: NASA
S73-27707 (9 June 1973) --- Astronaut Charles Conrad Jr., Skylab 2 commander, serves as test subject for the Lower Body Negative Pressure (MO92) Experiment, as seen in this reproduction taken from a color television transmission made by a TV camera aboard the Skylab 1/2 space station cluster in Earth orbit. Scientist-astronaut Joseph P. Kerwin, Skylab 2 science pilot, assists Conrad into the LBNP device. Kerwin served as monitor for the experiment. The purpose of the MO92 experiment is to provide information concerning the time course of cardiovascular adaptation during flight, and to provide inflight data for predicting the degree of orthostatic intolerance and impairment of physical capacity to be expected upon return to Earth environment. The data collected in support of MO92 blood pressure, heart rate, body temperature, vectorcardiogram, LBNPD pressure, leg volume changes, and body weight. Photo credit: NASA
ISS014-E-08795 (29 Nov. 2006) --- European Space Agency (ESA) astronaut Thomas Reiter, Expedition 14 flight engineer, works with the Cognitive Cardiovascular (Cardiocog-2) experiment in the Zvezda Service Module of the International Space Station. Cardiocog-2 will determine the impact of weightlessness on the cardiovascular system and respiratory system and the cognitive reactions of crewmembers. The results of this study will be used to develop additional countermeasures that will continue to keep crewmembers healthy during long-duration space exploration.
ISS015-E-08659 (May 2007) --- Cosmonaut Oleg V. Kotov, Expedition 15 flight engineer representing Russia's Federal Space Agency, checks procedures checklists while collecting medical data for the Cognitive Cardiovascular (Cardiocog-2) experiment in the Zvezda Service Module of the International Space Station. Cardiocog-2 will determine the impact of weightlessness on the cardiovascular system and respiratory system and the cognitive reactions of crewmembers. The results of this study will be used to develop additional countermeasures that will continue to keep crewmembers healthy during long-duration space exploration.
ISS015-E-08660 (May 2007) --- Cosmonaut Oleg V. Kotov, Expedition 15 flight engineer representing Russia's Federal Space Agency, collects medical data for the Cognitive Cardiovascular (Cardiocog-2) experiment in the Zvezda Service Module of the International Space Station. Cardiocog-2 will determine the impact of weightlessness on the cardiovascular system and respiratory system and the cognitive reactions of crewmembers. The results of this study will be used to develop additional countermeasures that will continue to keep crewmembers healthy during long-duration space exploration.
ISS015-E-08661 (May 2007) --- Cosmonaut Oleg V. Kotov, Expedition 15 flight engineer representing Russia's Federal Space Agency, collects medical data for the Cognitive Cardiovascular (Cardiocog-2) experiment in the Zvezda Service Module of the International Space Station. Cardiocog-2 will determine the impact of weightlessness on the cardiovascular system and respiratory system and the cognitive reactions of crewmembers. The results of this study will be used to develop additional countermeasures that will continue to keep crewmembers healthy during long-duration space exploration.
iss066e086655 (Dec. 6, 2021) --- NASA astronaut and Expedition 66 Flight Engineer Thomas Marshburn sets up hardware for the Vascular Echo human research study that examines the cardiovascular changes that take place in microgravity.
S93-45364 (29 Sept 1993) --- Astronaut David A. Wolf, mission specialist, participates in pre-flight data collection for the cardiovascular experiments scheduled to fly aboard Columbia for the Spacelab Life Sciences (SLS-2) mission.
jsc2019e041779 (7/25/2019) --- A view of Dr. Josephine Allen assembling the KEU-RO experiment units for STaARS BioScience-3 experiment. The Spaceflight Effects on Vascular Endothelial and Smooth Muscle Cell Process (STaARS BioScience-3) investigation contributes to a greater understanding of cardiovascular disease (CVD) through the study of transcriptomics of vascular cells. Upon return from spaceflight, crew members often display alterations in their cardiovascular systems, similar to those suffering from CVD. The goal of this work is to elucidate the mechanism of vascular cell damage in the space environment by exposing vascular cells to spaceflight.
jsc2019e041776 (10/2/2012) --- A preflight phase contrast image of vascular endothelial cells cultured on microcarrier beads before being put into the flight hardware. Used for STaARS BioScience-3 experiment. The Spaceflight Effects on Vascular Endothelial and Smooth Muscle Cell Process (STaARS BioScience-3) investigation contributes to a greater understanding of cardiovascular disease (CVD) through the study of transcriptomics of vascular cells. Upon return from spaceflight, crew members often display alterations in their cardiovascular systems, similar to those suffering from CVD. The goal of this work is to elucidate the mechanism of vascular cell damage in the space environment by exposing vascular cells to spaceflight.
jsc2019e041778 (7/25/2019) --- A view of Dr. Marina Scotti viewing the cells on the microscope for STaARS BioScience-3 experiment. The Spaceflight Effects on Vascular Endothelial and Smooth Muscle Cell Process (STaARS BioScience-3) investigation contributes to a greater understanding of cardiovascular disease (CVD) through the study of transcriptomics of vascular cells. Upon return from spaceflight, crew members often display alterations in their cardiovascular systems, similar to those suffering from CVD. The goal of this work is to elucidate the mechanism of vascular cell damage in the space environment by exposing vascular cells to spaceflight.
jsc2019e041782 (7/25/2019) --- A preflight image of the KEU-RO experiment units for STaARS BioScience-3 experiment. The Spaceflight Effects on Vascular Endothelial and Smooth Muscle Cell Process (STaARS BioScience-3) investigation contributes to a greater understanding of cardiovascular disease (CVD) through the study of transcriptomics of vascular cells. Upon return from spaceflight, crew members often display alterations in their cardiovascular systems, similar to those suffering from CVD. The goal of this work is to elucidate the mechanism of vascular cell damage in the space environment by exposing vascular cells to spaceflight.
jsc2019e041780 (7/25/2019) --- A preflight image of the KEU-RO experiment units for STaARS BioScience-3 experiment. The Spaceflight Effects on Vascular Endothelial and Smooth Muscle Cell Process (STaARS BioScience-3) investigation contributes to a greater understanding of cardiovascular disease (CVD) through the study of transcriptomics of vascular cells. Upon return from spaceflight, crew members often display alterations in their cardiovascular systems, similar to those suffering from CVD. The goal of this work is to elucidate the mechanism of vascular cell damage in the space environment by exposing vascular cells to spaceflight.
ISS032-E-011853 (1 Aug. 2012) --- NASA astronaut Joe Acaba (left) and Japan Aerospace Exploration Agency astronaut Aki Hoshide, both Expedition 32 flight engineers, perform an Integrated Cardiovascular (ICV) Resting Echo Scan at the Human Research Facility (HRF) rack in the Columbus laboratory of the International Space Station.
ISS030-E-155942 (20 Jan. 2012) --- NASA astronaut Dan Burbank, Expedition 30 commander, prepares to use the Integrated Cardiovascular (ICV) Resting Echo Scan on a crew member (out of frame) at the Human Research Facility (HRF) rack in the Columbus laboratory of the International Space Station.
iss065e069159 (May 25, 2021) --- Expedition 65 Commander Akihiko Hoshide of the Japan Aerospace Exploration Agency scans the femoral artery in his right leg with an ultrasound device for the Vascular Aging study. The human research experiment explores how long-term spaceflight affects an astronaut's cardiovascular risk.
ISS026-E-015924 (7 Jan. 2011) --- NASA astronaut Catherine (Cady) Coleman, Expedition 26 flight engineer, participates in the ambulatory monitoring part of the Integrated Cardiovascular (ICV) assessment research experiment in the Kibo laboratory of the International Space Station.
ISS030-E-155938 (20 Jan. 2012) --- NASA astronaut Dan Burbank, Expedition 30 commander, sets up the Integrated Cardiovascular (ICV) Resting Echo Scan at the Human Research Facility (HRF) rack in the Columbus laboratory of the International Space Station.
iss073e0702307 (Sept. 17, 2025) --- NASA astronaut and Expedition 73 Flight Engineer Mike Fincke pedals on the International Space Station's exercise cycle, also known as Cycle Ergometer with Vibration Isolation and Stabilization, or CEVIS, providing aerobic and cardiovascular conditioning in microgravity.
STS040-211-019 (5-14 June 1991) --- Astride the bicycle ergometer, astronaut Rhea Seddon, mission specialist, breathes into the cardiovascular re-breathing unit during the exercise phase of an experiment. The investigation, In-flight Study of Cardiovascular Deconditioning (Experiment 066), was developed by Dr. Leon E. Farhi of the State University of New York in Buffalo. It focuses on the deconditioning of the heart and lungs and changes in cardiopulmonary function that occur upon return to Earth. By using non-invasive techniques of prolonged expiration and re-breathing, investigators can determine the amount of blood pumped out of the heart (cardiac output), the ease with which blood flows through all the vessels (total peripheral resistance), oxygen used and carbon dioxide released by the body, and lung function and volume changes. Measurements are made both while crew members are resting and while they pedal the exercise bicycle, as Dr. Seddon is doing here. This scene was photographed with a 35mm camera.
This is a wide-angle view of the Orbital Workshop lower level experiment area. In center foreground is the ergometer bicycle. In center background is a litter chair for the Human Vestibular Function experiment (Skylab Experiment M131) and in right background is the Lower Body Negative Pressure System experiment (Skylab Experiment M092). The ergometer bicycle was used for metabolic activity experiments and exercise. The purpose of the Human Vestibular (irner ear) Function experiment was to examine the effect of weightlessness on man's sensitivity and susceptibility to motion rotation, and his perception of orientation. The Lower Body Negative Pressure experiment investigated the relationship between the zero gravity environment and cardiovascular deconditioning. A characteristic of cardiovascular deconditoning is the partial failure of the blood vessels resulting in the excessive pooling of the blood in the legs when a person assumes an erect posture in a gravity field. The Marshall Space Flight Center had the program management responsibility for the development of Skylab hardware and experiments.
ISS042E082884 (12/27/2014) --- Expedition 42 Flight Engineer Terry Virts of NASA straps into the station’s stationary exercise bicycle known as the Cycle Ergometer with Vibration Isolation System (CEVIS). Each crew member spends an average of 2.5 hours a day exercising to combat the negative effects of prolonged weightlessness by maintaining bone and muscle mass and cardiovascular health.
ISS026-E-015923 (7 Jan. 2011) --- NASA astronaut Catherine (Cady) Coleman, Expedition 26 flight engineer, participates in the ambulatory monitoring part of the Integrated Cardiovascular (ICV) assessment research experiment in the Kibo laboratory of the International Space Station. Coleman is wearing electrodes, a Holter Monitor 2 (HM2) for recording Electrocardiogram (ECG), a European Space Agency (ESA) Cardio pressure / Blood Pressure unit to continuously monitor blood pressure and two Actiwatches (hip/waist and ankle) for monitoring activity levels.
iss072e035666 (Oct. 11, 2024) --- NASA astronauts Matthew Dominick and Jeanette Epps (rear center), both Expedition 72 Flight Engineers, are pictured during a variety of activities aboard the International Space Station. Dominick is pedaling on the Cycle Ergometer with Vibration Isolation and Stabilization (CEVIS), an exercise cycle providing aerobic and cardiovascular conditioning inside the Destiny laboratory module. Epps is in the Harmony module exploring how to water plants in the microgravity environment for the Plant Water Management 5 space botany investigation.
S93-45375 (29 Sept 1993) --- Astronaut David A. Wolf, STS-58 mission specialist, has blood drawn from his leg for volume measuring. The blood draw was part of the cardiovascular function data collection in preparation for the Spacelab Life Sciences (SLS-2) mission. The seven Spacelab Life Sciences crewmembers devoted a full day to miscellaneous biomedical data collection in preparation for next month's two week mission aboard Columbia.
Expedition 10 Commander Leroy Chiao undergoes physical testing on a mechanized tilt table at crew quarters in Baikonur, Kazakhstan, Friday, October 8, 2004, in preparation for launch with Flight Engineer and Soyuz Commander Salizhan Sharipov and Russian Space Forces Agency cosmonaut Yuri Shargin to the International Space Station on October 14. The tilt table is used to condition the crewmembers' cardiovascular system against the effects of weightlessness once on orbit. Photo Credit: (NASA/Bill Ingalls)
This Skylab-2 onboard photograph shows astronaut Charles "Pete" Conrad exercising on a stationary bicycle (ergometer) used for monitoring the metabolism of the astronauts. The ergometer was used to conduct both Vectorcardiogram experiment (M093) and Metabolic Activity experiment (M171). Experiment M093 was a medical evaluation designed to monitor changes in astronauts' cardiovascular systems, while Experiment M171 was to measure astronauts' metabolic changes during long-duration space missions.
iss072e034702 (Oct. 10, 2024) --- NASA astronaut and Expedition 72 Flight Engineer Nick Hague pedals on the Cycle Ergometer with Vibration Isolation and Stabilization (CEVIS), an exercise cycle located aboard the International Space Station's Destiny laboratory module. CEVIS provides aerobic and cardiovascular conditioning through recumbent (leaning back position) or upright cycling activities.
iss070e075298 (Jan. 19, 2024) --- Expedition 70 Flight Engineer and JAXA (Japan Aerospace Exploration Agency) astronaut Satoshi Furukawa jogs on the Combined Operational Load Bearing External Resistance Treadmill (COLBERT) inside the International Space Station's Tranquility module. COLBERT is designed to allow walking and running in a microgravity environment for maintaining crew cardiovascular fitness, muscular strength, and to exercise neurophysiological pathways and reflexes that are required to walk once returned to Earth.
ISS038-E-007119 (21 Nov. 2013) --- Japan Aerospace Exploration Agency astronaut Koichi Wakata, Expedition 38 flight engineer, wears ultrasound gear around his legs while performing the Integrated Resistance and Aerobic Training Study (Sprint) experiment in the Columbus laboratory of the International Space Station. Sprint evaluates the use of high intensity, low volume exercise training to minimize loss of muscle, bone, and cardiovascular function in station crew members during long-duration missions.
Expedition 10 Commander Leroy Chiao undergoes physical testing on a mechanized tilt table at crew quarters in Baikonur, Kazakhstan, Friday, October 8, 2004, in preparation for launch with Flight Engineer and Soyuz Commander Salizhan Sharipov and Russian Space Forces Agency cosmonaut Yuri Shargin to the International Space Station on October 14. The tilt table is used to condition the crewmembers' cardiovascular system against the effects of weightlessness once on orbit. Photo Credit: (NASA/Bill Ingalls)
Expedition 10 Commander Leroy Chiao, left, and Russian Space Forces cosmonaut Yuri Shargin undergo physical testing on a mechanized tilt table at their crew quarters in Baikonur, Kazakhstan, Friday, October 8, 2004, in preparation for launch with Flight Engineer and Soyuz Commander Salizhan Sharipov to the International Space Station on October 14. The tilt table is used to condition the crewmembers' cardiovascular system against the effects of weightlessness once in orbit. Photo Credit: (NASA/Bill Ingalls)
Expedition 10 Commander Leroy Chiao undergoes physical testing on a mechanized tilt table at crew quarters in Baikonur, Kazakhstan, Friday, October 8, 2004, in preparation for launch with Flight Engineer and Soyuz Commander Salizhan Sharipov and Russian Space Forces Agency cosmonaut Yuri Shargin to the International Space Station on October 14. The tilt table is used to condition the crewmembers' cardiovascular system against the effects of weightlessness once on orbit. Photo Credit: (NASA/Bill Ingalls)
jsc2022e083017 (4/23/2022) --- A preflight image of a BioCell developed by BioServe Space Technologies that contains 162 beating cardiac spheroids derived from induced pluripotent stem cells (iPSCs). These cells are incubated and put under the microscope in space as part of the Effect of Microgravity on Drug Responses Using Heart Organoids (Cardinal Heart 2.0) investigation. Image courtesy of Drs. Joseph Wu, Dilip Thomas and Xu Cao, Stanford Cardiovascular Institute.
jsc2022e083018 (10/26/2022) --- A preflight image of beating cardiac spheroid composed of iPSC-derived cardiomyocytes (CMs), endothelial cells (ECs), and cardiac fibroblasts (CFs). These cells are incubated and put under the microscope in space as part of the Effect of Microgravity on Drug Responses Using Heart Organoids (Cardinal Heart 2.0) investigation. Image courtesy of Drs. Joseph Wu, Dilip Thomas and Xu Cao, Stanford Cardiovascular Institute.
ISS009-E-13739 (5 July 2004) --- Cosmonaut Gennady I. Padalka, Expedition 9 commander representing Russia’s Federal Space Agency, works with the Cardiocog experiment in the Zvezda Service Module of the International Space Station (ISS). Originally part of Pedro Duque's VC5 "Cervantes" science program, Cardiocog studies changes in the human cardiovascular system in micro-G, expressed in the peripheral arteries, and the vegetative regulation of arterial blood pressure and heart rate.
iss058e003984 (1/16/2019) --- Canadian Space Agency (CSA) astronaut David Saint-Jacques demonstrates the Bio-Monitor, a Canadian technology, which is utilized in the Autonomous Health Monitoring for Adaption Assessment on Long Range Missions Using Big Data Analytic.(Space Health) study. The innovative smart shirt system captures the astronauts' vital signs, and the data is used to assess the impact of spaceflight on the cardiovascular system. Image courtesy of CSA/NASA.
iss070e009186 (Oct. 25, 2023) --- NASA astronaut and Expedition 70 Flight Engineer Loral O'Hara pedals on an exercise cycle, also known as CEVIS, or Cycle Ergometer Vibration Isolation System, inside the International Space Station's Destiny laboratory module. The CEVIS provides aerobic and cardiovascular conditioning and supports science activities, pre-breathe spacewalk activities, periodic fitness evaluations, and pre-landing fitness evaluations.
S93-45371 (29 Sept 1993) --- Astride the bicycle ergometer, Martin J. (Marty) Fettman, DVM, breathes quietly into the cardiovascular re-breathing unit during the resting phase of an experiment. The payload specialist for the Spacelab Life Sciences (SLS-2) mission was participating with six NASA astronauts, also assigned to STS-58, for data collection and training.
STS-32 crewmembers test the inflight lower body negative pressure (LBNP) device. Mission Specialist (MS) Bonnie J. Dunbar (lying down) inside the cylindrical LBNP device prepares for testing as principal investigator Dr. John Charles, a cardiovascular scientist in JSC's Space Biomedical Research Institute, and Michele Jones, a KRUG International biomedical engineer, review procedures with MS G. David Low. The inflight LBNP will be part of detailed supplementary objective (DSO) 0478. Photo taken by JSC photographer Jack Jacob.
iss072e126509 (Oct. 29, 2024) --- NASA astronaut and Expedition 72 Flight Engineer Nick Hague exercises on the advanced resistive exercise device (ARED) aboard the International Space Station's Tranquility module. The ARED mimics the inertial forces of lifting free weights on Earth to maintain muscle health during long-term space missions. During his exercise session, Hague wore Bio-Monitor, a garment and headband set outfitted with sensors to collect physiological data and minimally interfere with space station life. Hague wore the garment 48 hours as part of Vascular Aging, a study that monitors an astronaut’s cardiovascular health in space.
Arn Harris Hoover of Lockheed Martin Company demonstrates an engineering mockup of the Human Research Facility (HRF) that will be installed in Destiny, the U.S. Laboratory Module on the International Space Station (ISS). Using facilities similar to research hardware available in laboratories on Earth, the HRF will enable systematic study of cardiovascular, musculoskeletal, neurosensory, pulmonary, radiation, and regulatory physiology to determine biomedical changes resulting from space flight. Research results obtained using this facility are relevant to the health and the performance of the astronaut as well as future exploration of space. Because this is a mockup, the actual flight hardware may vary as desings are refined. (Credit: NASA/Marshall Space Flight Center)
This 1970 photograph shows Skylab's In-Flight Lower Body Negative Pressure experiment facility, a medical evaluation designed to monitor changes in astronauts' cardiovascular systems during long-duration space missions. This experiment collected in-flight data for predicting the impairment of physical capacity and the degree of orthostatic intolerance to be expected upon return to Earth. Data to be collected were blood pressure, heart rate, body temperature, vectorcardiogram, lower body negative pressure, leg volume changes, and body mass. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.
This chart details Skylab's In-Flight Lower Body Negative Pressure experiment facility, a medical evaluation designed to monitor changes in astronauts' cardiovascular systems during long-duration space missions. This experiment collected in-flight data for predicting the impairment of physical capacity and the degree of orthostatic intolerance to be expected upon return to Earth. Data to be collected were blood pressure, heart rate, body temperature, vectorcardiogram, lower body negative pressure, leg volume changes, and body mass. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.
jsc2025e057712 (1/10/2025) --- DrainBrain 2.0 examines how blood flows from the brain to the heart in microgravity. Results could help researchers identify which processes in the body compensate for the lack of gravity, helping to ensure proper blood flow for astronauts and people with cardiovascular issues on Earth. This photo shows the University of Ferrara/Italian Space Agency (ASI) research team, left to right, Anselmo Pagani, Rosa Brancaccio, Antonino Proto, Chiara Marchesin, Ilaria Manfrini, Bruno Soggia, Angelo Taibi, and Principal Investigator Paolo Zamboni.
ISS047e134605 (05/30/2016) --- ESA (European Space Agency) astronaut Tim Peake uses hardware for the Vascular Echo experiment. As humans get older on Earth, arteries stiffen and this causes an increase in blood pressure (hypertension) and elevates the risk for cardiovascular disease. Recently, it has been observed that some crew members returning from the International Space Station (ISS) have much stiffer arteries than when they went into space. The results from studying these changes could provide insight into potential countermeasures to help maintain crew member health, and quality of life for everyone.
ISS035-E-022356 (17 April 2013) --- In support of the Blood Pressure Regulation Experiment (BP Reg), Expedition 35 Commander Chris Hadfield of the Canadian Space Agency is pictured after having set up the Human Research Facility (HRF) PFS (Pulmonary Function System) and the European Physiology Module (EPM) Cardiolab (CDL) Leg/Arm Cuff System (LACS) and conducting the first ever session of this experiment. The test, which will be repeated using other crew members as well, will help to identify the astronauts who could benefit from countermeasures before returning to Earth. Thus, this method has great potential for astronaut health monitoring during future long-term space flights and it also has important implications for testing of individuals on Earth, especially the elderly, who are at risk for fainting. The research will also allow demonstrating the feasibility of obtaining a set of indicators of overall cardiovascular regulation from the non-invasive measurement of continuous blood pressure.
STS-40 Payload Specialist Millie Hughes-Fulford along with backup payload specialist Robert Ward Phillips familiarize themselves with Spacelab Life Sciences 1 (SLS-1) equipment. The two scientists are in JSC's Life Sciences Project Division (LSPD) SLS mockup located in the Bioengineering and Test Support Facility Bldg 36. Hughes-Fulford, in the center aisle, pulls equipment from an overhead stowage locker while Phillips, in the foreground, experiments with the baroreflex neck pressure chamber at Rack 11. The baroreflex collar will be used in conjuction with Experiment No. 022, Influence of Weightlessness Upon Human Autonomic Cardiovascular Control. Behind Phillips in the center aisle are body mass measurement device (BMMD) (foreground) and the stowed bicycle ergometer.
ISS035-E-022360 (17 April 2013) --- In support of the Blood Pressure Regulation Experiment (BP Reg), Expedition 35 Commander Chris Hadfield of the Canadian Space Agency is pictured after having set up the Human Research Facility (HRF) PFS (Pulmonary Function System) and the European Physiology Module (EPM) Cardiolab (CDL) Leg/Arm Cuff System (LACS) and conducting the first ever session of this experiment. The test, which will be repeated using other crew members as well, will help to identify the astronauts who could benefit from countermeasures before returning to Earth. Thus, this method has great potential for astronaut health monitoring during future long-term space flights and it also has important implications for testing of individuals on Earth, especially the elderly, who are at risk for fainting. The research will also allow demonstrating the feasibility of obtaining a set of indicators of overall cardiovascular regulation from the non-invasive measurement of continuous blood pressure.
ISS035-E-022357 (17 April 2013) --- In support of the Blood Pressure Regulation Experiment (BP Reg), Expedition 35 Commander Chris Hadfield of the Canadian Space Agency is pictured after having set up the Human Research Facility (HRF) PFS (Pulmonary Function System) and the European Physiology Module (EPM) Cardiolab (CDL) Leg/Arm Cuff System (LACS) and conducting the first ever session of this experiment. The test, which will be repeated using other crew members as well, will help to identify the astronauts who could benefit from countermeasures before returning to Earth. Thus, this method has great potential for astronaut health monitoring during future long-term space flights and it also has important implications for testing of individuals on Earth, especially the elderly, who are at risk for fainting. The research will also allow demonstrating the feasibility of obtaining a set of indicators of overall cardiovascular regulation from the non-invasive measurement of continuous blood pressure.
The laboratory module in the cargo bay of the Space Shuttle Orbiter Columbia was photographed during the Spacelab Life Science-1 (SLS-1) mission. SLS-1 was the first Spacelab mission dedicated solely to life sciences. The main purpose of the SLS-1 mission was to study the mechanisms, magnitudes, and time courses of certain physiological changes that occur during space flight, to investigate the consequences of the body's adaptation to microgravity and readjustment to Earth's gravity, and to bring the benefits back home to Earth. The mission was designed to explore the responses of the heart, lungs, blood vessels, kidneys, and hormone-secreting glands to microgravity and related body fluid shifts; examine the causes of space motion sickness; and study changes in the muscles, bones and cells. The five body systems being studied were: The Cardiovascular/Cardiopulmonary System (heart, lungs, and blood vessels), the Renal/Endocrine System (kidney and hormone-secreting organs), the Immune System (white blood cells), the Musculoskeletal System (muscles and bones), and the Neurovestibular System (brain and nerves, eyes, and irner ear). The SLS-1 was launched aboard the Space Shuttle Orbiter Columbia (STS-40) on June 5, 1995.
S93-45363 (29 Sept 1993) --- Payload specialist Martin J. Fettman, in an oscillating sled device, participates in a data collection project for neurovestibular functions. The seven Spacelab Life Sciences (SLS-2) crewmembers devoted a full day to miscellaneous biomedical data collection in preparation for next month's two week mission aboard Columbia.
S93-45373 (29 Sept 1993) --- Astronaut Rhea Seddon, STS-58 payload commander, is in a piloting simulator as part of a pre-flight data collection project for neurovestibular functions. The seven Spacelab Life Sciences (SLS-2) crew members devoted a full day to miscellaneous biomedical data collection in preparation for next month's two week mission aboard Columbia.
Astronaut Chiaki Mukai conducts the Lower Body Negative Pressure (LBNP) experiment inside the International Microgravity Laboratory-2 (IML-2) mission science module. Dr. Chiaki Mukai is one of the National Space Development Agency of Japan (NASDA) astronauts chosen by NASA as a payload specialist (PS). She was the second NASDA PS who flew aboard the Space Shuttle, and was the first female astronaut in Asia. When humans go into space, the lack of gravity causes many changes in the body. One change is that fluids normally kept in the lower body by gravity shift upward to the head and chest. This is why astronauts' faces appear chubby or puffy. The change in fluid volume also affects the heart. The reduced fluid volume means that there is less blood to circulate through the body. Crewmembers may experience reduced blood flow to the brain when returning to Earth. This leads to fainting or near-fainting episodes. With the use of the LBNP to simulate the pull of gravity in conjunction with fluids, salt tablets can recondition the cardiovascular system. This treatment, called "soak," is effective up to 24 hours. The LBNP uses a three-layer collapsible cylinder that seals around the crewmember's waist which simulates the effects of gravity and helps pull fluids into the lower body. The data collected will be analyzed to determine physiological changes in the crewmembers and effectiveness of the treatment. The IML-2 was the second in a series of Spacelab flights designed by the international science community to conduct research in a microgravity environment Managed by the Marshall Space Flight Center, the IML-2 was launched on July 8, 1994 aboard the STS-65 Space Shuttle Orbiter Columbia mission.
A data visualization shows the average concentration of PM2.5 particulate pollution in the Los Angeles region from 2000 to 2018, along with the locations of nearly 11,000 warehouses over the same time period. Particles measuring 2.5 micrometers or less, PM2.5 are pollutants that can be inhaled into the lungs and absorbed into the bloodstream. A NASA-funded study published in September 2024 in GeoHealth analyzed patterns and trends of atmospheric PM2.5 concentration and found that ZIP codes with more or larger warehouses had higher levels of PM2.5 and elemental carbon over time than those with fewer warehouses. Elemental carbon is a type of PM2.5 that is produced by heavy-duty diesel engines. In the visualization, areas with higher concentrations of PM2.5 are shown in darker red, and locations of warehouses are indicated by small black circles (many of them clustered closely together). The PM2.5 data came from models based on satellite observations, including from NASA's Moderate Resolution Imaging Spectroradiometer (MODIS) and Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) instruments. The PM2.5 warehouse locations were derived from a commercial real estate database. Particulate pollution has been linked to respiratory and cardiovascular diseases, some cancers, and adverse birth outcomes, including premature birth and low infant birth weight. As the e-commerce boom of recent decades has spurred warehouse construction, pollution in nearby neighborhoods has become a growing area for research. https://photojournal.jpl.nasa.gov/catalog/PIA26415
The first United States Microgravity Laboratory (USML-1) flew in orbit inside the Spacelab science module for extended periods, providing scientists and researchers greater opportunities for research in materials science, fluid dynamics, biotechnology (crystal growth), and combustion science. In this photograph, Astronaut Bornie Dunbar and Astronaut Larry DeLucas are conducting the Lower Body Negative Pressure (LBNP) experiment, which is to protect the health and safety of the crew and to shorten the time required to readapt to gravity when they return to Earth. When humans go into space, the lack of gravity causes many changes in the body. One change is that fluids normally kept in the lower body by gravity, shift upward to the head and chest. This is why astronauts' faces appear chubby or puffy. The change in fluid volume also affects the heart. The reduced fluid volume means that there is less blood to circulate through the body. Crewmembers may experience reduced blood flow to the brain when returning to Earth. This leads to fainting or near-fainting episodes. With the use of LBNP to simulate the pull of gravity in conjunction with fluids, salt tablets can recondition the cardiovascular system. This treatment, called "soak," is effective up to 24 hours. The LBNP uses a three-layer collapsible cylinder that seals around the crewmember's waist which simulates the effects of gravity and helps pull fluids into the lower body. The data collected will be analyzed to determine physiological changes in the crewmembers and effectiveness of the treatment. The USML-1 was launched aboard the Space Shuttle Orbiter Columbia (STS-50) on June 25, 1992.