The C-140 JetStar was reconfigured as the General Purpose Airborne Simulator (GPAS) to simulate the flight characteristics of other aircraft. The JetStar was used for research for supersonic transports, general aviation aircraft, and as a training support aircraft for the Space Shuttle Approach and Landing tests at Dryden Flight Research Center (under different names) at Edwards, CA, in 1977. One of the engineers on the GPAS program was Ken Szalai, who later became Dryden's director from 1990 to August 1998.

The NASA C-140 JetStar research aircraft (top) is followed by a NASA Learjet equipped with acoustic sensors during one of several tests of advanced propellors mounted on the vertical pylon atop the JetStar's fuselage. Several advanced prop designs were tested on the JetStar in 1982 by NASA's Dryden Flight Research Facility (DFRF), Edwards, California, to study the effects of noise created by propellors on aircraft structures and cabin interiors. To assess possible noise problems with the subscale turbofan, DFRF technicians mounted microphones on both the JetStar and the Learjet chase plane. DFRF then made measurements at close range and at longer distances. The data enabled structural changes and flightpath modifications.

Researchers at the National Advisory Committee for Aeronautics (NACA) Lewis Flight Propulsion Laboratory purposely crash a Fairchild C-82 Packet aircraft to study flame propagation. A rash of passenger aircraft crashes in 1946 and 1947 spurred a White House call for an investigatory board staffed by members of the Civil Aeronautics Board, military, and the NACA. The group addressed fire segregation, extinguishment, and prevention. The NACA established a Subcommittee on Aircraft Fire Prevention in February 1948 to coordinate its efforts. The Lewis team simulated situations in which an aircraft failed to become airborne during takeoff resulting in crashes into embankments and other objects. The Lewis researchers initially used surplus C-46 and C-82 military transport planes. In these situations, the aircraft generally suffered damage to its fuel system and other components, but was structurally survivable. The aircraft were mounted to a rail that ran down a 1700-foot long test runway. The aircraft was secured at the starting point with an anchor pier so it could get its engines up to takeoff speed before launching down the track. Barriers at the end of the runway were designed to simulate a variety of different types of crashes. Telemetry and high-speed cameras were crucial elements in these studies. The preliminary testing phase identified potential ignition sources and analyzed the spread of flammable materials.

The Dryden C-140 JetStar during testing of advanced propfan designs. Dryden conducted flight research in 1981-1982 on several designs. The technology was developed under the direction of the Lewis Research Center (today the Glenn Research Center, Cleveland, OH) under the Advanced Turboprop Program. Under that program, Langley Research Center in Virginia oversaw work on accoustics and noise reduction. These efforts were intended to develop a high-speed and fuel-efficient turboprop system.