STS047-230-030 (12 - 20 Sept 1992) --- Astronauts Mae C. Jemison (left) and N. Jan Davis, mission specialists, are pictured in the Spacelab-J science module preparing to conduct a session with the Lower Body Negative Pressure (LBNP) experiment. The two joined four other NASA astronauts and a payload specialist representing Japan's National Space Development Agency (NASDA) aboard the Earth-orbiting Space Shuttle Endeavour for eight days of Spacelab-J research.

STS047-46-027 (12-20 Sept. 1992) --- Astronauts N. Jan Davis (left) and Mae C. Jemison, STS-47 mission specialists, prepare to deploy the Lower Body Negative Pressure (LBNP) apparatus in this 35mm frame photographed in the Science Module aboard the Earth-orbiting Space Shuttle Endeavour. Making their first flight in space, the two were joined by four other NASA astronauts and a Japanese payload specialist for eight days of research. The Spacelab-J mission is a joint effort between Japan and the United States of America.

STS050-291-027 (25 June-9 July 1992) --- Astronaut Bonnie J. Dunbar uses a Doppler to collect medical data from Lawrence J. DeLucas, payload specialist, during his diagnostic "run" in the Lower Body Negative Pressure device (LBNP). The Doppler is used to pick up high-frequency sound waves from the surface of the heart, thus producing pictures on the monitor of the American Flight Echocardiograph (AFE). The result of the LBNP procedure is expected to be an increased tolerance of orthostatis - or standing upright - upon return to Earth's gravity. LBNP has been used a number of times in the United States space program, as early as the Skylab missions. STS-50 is the fourth flight of the current collapsible unit. Researchers are refining the LBNP protocol which will be used operationally on future 13 through 16 day missions.

The first United States Microgravity Laboratory (USML-1) flew in orbit inside the Spacelab science module for extended periods, providing scientists and researchers greater opportunities for research in materials science, fluid dynamics, biotechnology (crystal growth), and combustion science. In this photograph, Astronaut Bornie Dunbar and Astronaut Larry DeLucas are conducting the Lower Body Negative Pressure (LBNP) experiment, which is to protect the health and safety of the crew and to shorten the time required to readapt to gravity when they return to Earth. When humans go into space, the lack of gravity causes many changes in the body. One change is that fluids normally kept in the lower body by gravity, shift upward to the head and chest. This is why astronauts' faces appear chubby or puffy. The change in fluid volume also affects the heart. The reduced fluid volume means that there is less blood to circulate through the body. Crewmembers may experience reduced blood flow to the brain when returning to Earth. This leads to fainting or near-fainting episodes. With the use of LBNP to simulate the pull of gravity in conjunction with fluids, salt tablets can recondition the cardiovascular system. This treatment, called "soak," is effective up to 24 hours. The LBNP uses a three-layer collapsible cylinder that seals around the crewmember's waist which simulates the effects of gravity and helps pull fluids into the lower body. The data collected will be analyzed to determine physiological changes in the crewmembers and effectiveness of the treatment. The USML-1 was launched aboard the Space Shuttle Orbiter Columbia (STS-50) on June 25, 1992.

Astronaut Chiaki Mukai conducts the Lower Body Negative Pressure (LBNP) experiment inside the International Microgravity Laboratory-2 (IML-2) mission science module. Dr. Chiaki Mukai is one of the National Space Development Agency of Japan (NASDA) astronauts chosen by NASA as a payload specialist (PS). She was the second NASDA PS who flew aboard the Space Shuttle, and was the first female astronaut in Asia. When humans go into space, the lack of gravity causes many changes in the body. One change is that fluids normally kept in the lower body by gravity shift upward to the head and chest. This is why astronauts' faces appear chubby or puffy. The change in fluid volume also affects the heart. The reduced fluid volume means that there is less blood to circulate through the body. Crewmembers may experience reduced blood flow to the brain when returning to Earth. This leads to fainting or near-fainting episodes. With the use of the LBNP to simulate the pull of gravity in conjunction with fluids, salt tablets can recondition the cardiovascular system. This treatment, called "soak," is effective up to 24 hours. The LBNP uses a three-layer collapsible cylinder that seals around the crewmember's waist which simulates the effects of gravity and helps pull fluids into the lower body. The data collected will be analyzed to determine physiological changes in the crewmembers and effectiveness of the treatment. The IML-2 was the second in a series of Spacelab flights designed by the international science community to conduct research in a microgravity environment Managed by the Marshall Space Flight Center, the IML-2 was launched on July 8, 1994 aboard the STS-65 Space Shuttle Orbiter Columbia mission.