iss052e004180 (6/19/2017) --- Photo of NASA astronaut Peggy Whitson performing change out of Imaging Unit on the Bone Densitometer (BD) located in Node 2.

iss052e004182 (6/19/2017) --- Photo of NASA astronaut Peggy Whitson performing change out of Imaging Unit on the Bone Desitometer (BD) located in Node 2.

STS085-336-018 (7 - 19 August 1997) --- Astronaut Robert L. Curbeam, Jr., mission specialist, with a Bioreactor Demonstration System (BDS-03) specimen on the mid-deck of the Space Shuttle Discovery.

BDS, Curbeam works with middeck experiment

S85-E-5011 (9 August 1997) --- Astronaut Robert L. Curbeam, Jr., mission specialist, works with the Bioreactor Demonstration System (BDS) on the Space Shuttle Discovery's mid-deck.

BDS - Curbeam works with middeck experiment

Leland W. K. Chung (left), Director, Molecular Urology Therapeutics Program at the Winship Cancer Institute at Emory University, is principal investigator for the NASA bioreactor demonstration system (BDS-05). With him is Dr. Jun Shu, an assistant professor of Orthopedics Surgery from Kuming Medical University China. The NASA Bioreactor provides a low turbulence culture environment which promotes the formation of large, three-dimensional cell clusters. Due to their high level of cellular organization and specialization, samples constructed in the bioreactor more closely resemble the original tumor or tissue found in the body. The Bioreactor is rotated to provide gentle mixing of fresh and spent nutrient without inducing shear forces that would damage the cells. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators. Credit: Emory University.

ISS039-E-016480 (30 April 2014) --- Russian cosmonauts Oleg Artemyev (right) and Alexander Skvortsov with Russia's Federal Space Agency (Roscosmos) work on the BD-2 treadmill in the Zvezda service module aboard the Earth-orbiting International Space Station.

Skvortsov and Artemyen conduct IFM on BD-2 Treadmill

Biotechnology

Diagram depicts the importance of cell-cell communication as central to the understanding of cancer growth and progression, the focus of the NASA bioreactor demonstration system (BDS-05) investigation. Microgravity studies will allow us to unravel the signaling and communication between these cells with the host and potential development of therapies for the treatment of cancer metastasis. The NASA Bioreactor provides a low turbulence culture environment which promotes the formation of large, three-dimensional cell clusters. Due to their high level of cellular organization and specialization, samples constructed in the bioreactor more closely resemble the original tumor or tissue found in the body. The Bioreactor is rotated to provide gentle mixing of fresh and spent nutrient without inducing shear forces that would damage the cells. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators. Credit: Emory University.

Astronaut Mary Ellen Weber with BDS

STS070-301-025 (13-22 July 1995) --- Astronaut Mary Ellen Weber works with a syringe related to the Bioreactor Development System (BDS). The almost weightless state of space travel provides life science researchers with the opportunity to grow cells into three-dimensional tissue pieces that are not achievable using conventional tissue culture methods on Earth. At specified times during the STS-70 mission, crew members injected color producing substances to document fluid movement in the reactor, and various-sized beads to estimate the tissue size that could be supported in the Bioreactor. The photo was among NASA's first release of still photography from the STS-70 mission. The mission was launched from the Kennedy Space Center (KSC) on July 13, 1995, and ended when Discovery landed on Runway 33 there on July 22, 1995. The crew members were astronauts Terence T. (Tom) Henricks, commander; Kevin R. Kregel, pilot; and Donald A. Thomas, Nancy J. Currie and Weber, all mission specialists.

Liftoff of MR-BD carrying a dummy capsule. Pad 5 Photo by: Special & Hopkins

jsc2024e081750 (12/17/2024) --- ONboard Globe-Looking And Imaging Satellite (ONGLAISAT) is a 6U size CubeSat aiming for high signal-to-noise ratio image capture using Time Delay Integration (TDI) technology as its mission. ONGLAISAT is deployed from the International Space Station as part of the JEM Small Satellite Orbital Deployer-30 (J-SSOD-30) CubeSat deployment mission. Image courtesy of Space BD Inc.

ISS011-E-05513 (5 May 2005) --- Cosmonaut Sergei K. Krikalev, Expedition 11 commander representing Russia's Federal Space Agency, poses beside the disconnected Liquid Unit #5 (BZh-5) and the O2 end-filter (BD, secondary purification unit) from the BZh5 he removed while making repairs to the Elektron oxygen generator in the Zvezda Service Module of the international space station.

Krikalev during Elektron repair

Microgravity

Bioreactor Demonstration System (BDS) comprises an electronics module, a gas supply module, and the incubator module housing the rotating wall vessel and its support systems. Nutrient media are pumped through an oxygenator and the culture vessel. The shell rotates at 0.5 rpm while the irner filter typically rotates at 11.5 rpm to produce a gentle flow that ensures removal of waste products as fresh media are infused. Periodically, some spent media are pumped into a waste bag and replaced by fresh media. When the waste bag is filled, an astronaut drains the waste bag and refills the supply bag through ports on the face of the incubator. Pinch valves and a perfusion pump ensure that no media are exposed to moving parts. An Experiment Control Computer controls the Bioreactor, records conditions, and alerts the crew when problems occur. The crew operates the system through a laptop computer displaying graphics designed for easy crew training and operation. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators. See No. 0101824 for a version with labels, and No. 0103180 for an operational schematic.

Microgravity

Bioreactor Demonstration System (BDS) comprises an electronics module, a gas supply module, and the incubator module housing the rotating wall vessel and its support systems. Nutrient media are pumped through an oxygenator and the culture vessel. The shell rotates at 0.5 rpm while the irner filter typically rotates at 11.5 rpm to produce a gentle flow that ensures removal of waste products as fresh media are infused. Periodically, some spent media are pumped into a waste bag and replaced by fresh media. When the waste bag is filled, an astronaut drains the waste bag and refills the supply bag through ports on the face of the incubator. Pinch valves and a perfusion pump ensure that no media are exposed to moving parts. An Experiment Control Computer controls the Bioreactor, records conditions, and alerts the crew when problems occur. The crew operates the system through a laptop computer displaying graphics designed for easy crew training and operation. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators. See No. 0101825 for a version with major elements labeled, and No. 0103180 for an operational schematic. 0101816

Microgravity

Bioreactor Demonstration System (BDS) comprises an electronics module, a gas supply module, and the incubator module housing the rotating wall vessel and its support systems. Nutrient media are pumped through an oxygenator and the culture vessel. The shell rotates at 0.5 rpm while the irner filter typically rotates at 11.5 rpm to produce a gentle flow that ensures removal of waste products as fresh media are infused. Periodically, some spent media are pumped into a waste bag and replaced by fresh media. When the waste bag is filled, an astronaut drains the waste bag and refills the supply bag through ports on the face of the incubator. Pinch valves and a perfusion pump ensure that no media are exposed to moving parts. An Experiment Control Computer controls the Bioreactor, records conditions, and alerts the crew when problems occur. The crew operates the system through a laptop computer displaying graphics designed for easy crew training and operation. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators. See No. 0101816 for a version without labels, and No. 0103180 for an operational schematic.

Microgravity

Bioreactor Demonstration System (BDS) comprises an electronics module, a gas supply module, and the incubator module housing the rotating wall vessel and its support systems. Nutrient media are pumped through an oxygenator and the culture vessel. The shell rotates at 0.5 rpm while the irner filter typically rotates at 11.5 rpm to produce a gentle flow that ensures removal of waste products as fresh media are infused. Periodically, some spent media are pumped into a waste bag and replaced by fresh media. When the waste bag is filled, an astronaut drains the waste bag and refills the supply bag through ports on the face of the incubator. Pinch valves and a perfusion pump ensure that no media are exposed to moving parts. An Experiment Control Computer controls the Bioreactor, records conditions, and alerts the crew when problems occur. The crew operates the system through a laptop computer displaying graphics designed for easy crew training and operation. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators. See No. 0101823 for a version without labels, and No. 0103180 for an operational schematic.

Hubble Sees a Star ‘Inflating’ a Giant Bubble

For the 26th birthday of NASA’s Hubble Space Telescope, astronomers are highlighting a Hubble image of an enormous bubble being blown into space by a super-hot, massive star. The Hubble image of the Bubble Nebula, or NGC 7635, was chosen to mark the 26th anniversary of the launch of Hubble into Earth orbit by the STS-31 space shuttle crew on April 24, 1990 “As Hubble makes its 26th revolution around our home star, the sun, we celebrate the event with a spectacular image of a dynamic and exciting interaction of a young star with its environment. The view of the Bubble Nebula, crafted from WFC-3 images, reminds us that Hubble gives us a front row seat to the awe inspiring universe we live in,” said John Grunsfeld, Hubble astronaut and associate administrator of NASA’s Science Mission Directorate at NASA Headquarters, in Washington, D.C. The Bubble Nebula is seven light-years across—about one-and-a-half times the distance from our sun to its nearest stellar neighbor, Alpha Centauri, and resides 7,100 light-years from Earth in the constellation Cassiopeia. The seething star forming this nebula is 45 times more massive than our sun. Gas on the star gets so hot that it escapes away into space as a “stellar wind” moving at over four million miles per hour. This outflow sweeps up the cold, interstellar gas in front of it, forming the outer edge of the bubble much like a snowplow piles up snow in front of it as it moves forward. As the surface of the bubble's shell expands outward, it slams into dense regions of cold gas on one side of the bubble. This asymmetry makes the star appear dramatically off-center from the bubble, with its location in the 10 o’clock position in the Hubble view. Dense pillars of cool hydrogen gas laced with dust appear at the upper left of the picture, and more “fingers” can be seen nearly face-on, behind the translucent bubble. The gases heated to varying temperatures emit different colors: oxygen is hot enough to emit blue light in the bubble near the star, while the cooler pillars are yellow from the combined light of hydrogen and nitrogen. The pillars are similar to the iconic columns in the “Pillars of Creation” Eagle Nebula. As seen with the structures in the Eagle Nebula, the Bubble Nebula pillars are being illuminated by the strong ultraviolet radiation from the brilliant star inside the bubble. The Bubble Nebula was discovered in 1787 by William Herschel, a prominent British astronomer. It is being formed by a proto-typical Wolf-Rayet star, BD +60º2522, an extremely bright, massive, and short-lived star that has lost most of its outer hydrogen and is now fusing helium into heavier elements. The star is about four million years old, and in 10 million to 20 million years, it will likely detonate as a supernova. Hubble’s Wide Field Camera-3 imaged the nebula in visible light with unprecedented clarity in February 2016. The colors correspond to blue for oxygen, green for hydrogen, and red for nitrogen. This information will help astronomers understand the geometry and dynamics of this complex system. The Bubble Nebula is one of only a handful of astronomical objects that have been observed with several different instruments onboard Hubble. Hubble also imaged it with the Wide Field Planetary Camera (WFPC) in September 1992, and with Wide Field Planetary Camera-2 (WFPC2) in April 1999. The Hubble Space Telescope is a project of international cooperation between NASA and the European Space Agency. NASA's Goddard Space Flight Center in Greenbelt, Maryland, manages the telescope. The Space Telescope Science Institute (STScI) in Baltimore, Maryland, conducts Hubble science operations. STScI is operated for NASA by the Association of Universities for Research in Astronomy in Washington, D.C. Credit: NASA, ESA, and the Hubble Heritage Team (STScI/AURA)

Hubble Sees a Star ‘Inflating’ a Giant Bubble

For the 26th birthday of NASA’s Hubble Space Telescope, astronomers are highlighting a Hubble image of an enormous bubble being blown into space by a super-hot, massive star. The Hubble image of the Bubble Nebula, or NGC 7635, was chosen to mark the 26th anniversary of the launch of Hubble into Earth orbit by the STS-31 space shuttle crew on April 24, 1990 “As Hubble makes its 26th revolution around our home star, the sun, we celebrate the event with a spectacular image of a dynamic and exciting interaction of a young star with its environment. The view of the Bubble Nebula, crafted from WFC-3 images, reminds us that Hubble gives us a front row seat to the awe inspiring universe we live in,” said John Grunsfeld, Hubble astronaut and associate administrator of NASA’s Science Mission Directorate at NASA Headquarters, in Washington, D.C. The Bubble Nebula is seven light-years across—about one-and-a-half times the distance from our sun to its nearest stellar neighbor, Alpha Centauri, and resides 7,100 light-years from Earth in the constellation Cassiopeia. The seething star forming this nebula is 45 times more massive than our sun. Gas on the star gets so hot that it escapes away into space as a “stellar wind” moving at over four million miles per hour. This outflow sweeps up the cold, interstellar gas in front of it, forming the outer edge of the bubble much like a snowplow piles up snow in front of it as it moves forward. As the surface of the bubble's shell expands outward, it slams into dense regions of cold gas on one side of the bubble. This asymmetry makes the star appear dramatically off-center from the bubble, with its location in the 10 o’clock position in the Hubble view. Dense pillars of cool hydrogen gas laced with dust appear at the upper left of the picture, and more “fingers” can be seen nearly face-on, behind the translucent bubble. The gases heated to varying temperatures emit different colors: oxygen is hot enough to emit blue light in the bubble near the star, while the cooler pillars are yellow from the combined light of hydrogen and nitrogen. The pillars are similar to the iconic columns in the “Pillars of Creation” Eagle Nebula. As seen with the structures in the Eagle Nebula, the Bubble Nebula pillars are being illuminated by the strong ultraviolet radiation from the brilliant star inside the bubble. The Bubble Nebula was discovered in 1787 by William Herschel, a prominent British astronomer. It is being formed by a proto-typical Wolf-Rayet star, BD +60º2522, an extremely bright, massive, and short-lived star that has lost most of its outer hydrogen and is now fusing helium into heavier elements. The star is about four million years old, and in 10 million to 20 million years, it will likely detonate as a supernova. Hubble’s Wide Field Camera-3 imaged the nebula in visible light with unprecedented clarity in February 2016. The colors correspond to blue for oxygen, green for hydrogen, and red for nitrogen. This information will help astronomers understand the geometry and dynamics of this complex system. The Bubble Nebula is one of only a handful of astronomical objects that have been observed with several different instruments onboard Hubble. Hubble also imaged it with the Wide Field Planetary Camera (WFPC) in September 1992, and with Wide Field Planetary Camera-2 (WFPC2) in April 1999. The Hubble Space Telescope is a project of international cooperation between NASA and the European Space Agency. NASA's Goddard Space Flight Center in Greenbelt, Maryland, manages the telescope. The Space Telescope Science Institute (STScI) in Baltimore, Maryland, conducts Hubble science operations. STScI is operated for NASA by the Association of Universities for Research in Astronomy in Washington, D.C. Credit: NASA, ESA, and the Hubble Heritage Team (STScI/AURA)