iss067e264450 (8/14/2022) --- A view aboard the International Space Station (ISS) of the Space Tango-Human Brain Organoids (BOARDS3) investigation. The Effect of Microgravity on Human Brain Organoids (Space Tango-Human Brain Organoids) observes the response of brain organoids to microgravity. This investigation demonstrates how exposure to microgravity affects survival, metabolism, and features of brain cells and, therefore, cognitive function.

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iss060e036685 (8/9/2019) — A view aboard the International Space Station (ISS) of the TangoLab Mission-13 CubeLabs: Space Tango-Human Brain Organoids and Space Tango-Induced Pluripotent Stem Cells. Space Tango-Induced Pluripotent Stem Cells examines how microglial cells grow and move in three-dimensional (3D) cultures as well as any changes in gene expression that occur as a result of microgravity exposure. Space Tango-Human Brain Organoids observes the response of brain organoids to microgravity.

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iss066e110840 (1/11/2022) --- A view of the Cosmic Brain Organoids CubeLab aboard the International Space Station (ISS). The Effects of Microgravity on Microglia 3-Dimensional Models of Parkinson’s Disease and Multiple Sclerosis – Mission 2 (Cosmic Brain Organoids) examines growth and movement of microglial cells in 3D organoids and potential changes in gene expression and protein secretion caused by microgravity.

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iss066e110844 (1/11/2022) --- A view of the Cosmic Brain Organoids CubeLab aboard the International Space Station (ISS). The Effects of Microgravity on Microglia 3-Dimensional Models of Parkinson’s Disease and Multiple Sclerosis – Mission 2 (Cosmic Brain Organoids) examines growth and movement of microglial cells in 3D organoids and potential changes in gene expression and protein secretion caused by microgravity.

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iss066e110849 (1/11/2022) --- A view of the Cosmic Brain Organoids CubeLab aboard the International Space Station (ISS). The Effects of Microgravity on Microglia 3-Dimensional Models of Parkinson’s Disease and Multiple Sclerosis – Mission 2 (Cosmic Brain Organoids) examines growth and movement of microglial cells in 3D organoids and potential changes in gene expression and protein secretion caused by microgravity.

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jsc2024e021220 (3/21/2024) --- Precursor cells are shown from the Human Brain Organoid Models for Neurodegenerative Disease & Drug Discovery (HBOND) investigation of primary progressive multiple sclerosis (MS). These Cosmic Brain Organoids will spend approximately 30 days on the International Space Station. This investigation studies 3D neuroglial organoids derived from the induced pluripotent stem cells (IPSCs) of patients with primary progressive MS and Parkinson’s disease. Results may improve understanding of neurodegenerative disease and accelerate the development of new treatments. Image courtesy of the New York Stem Cell Research Institute.

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iss070e129569 (March 26, 2024) --- Expedition 70 Flight Engineer and NASA astronaut Mike Barratt processes brain organoid samples inside the BioServe Tissue Chamber. The research work was being done to learn how microgravity affects the central nervous system and develop therapies to counteract neurodegenerative diseases both in space and on Earth. The Human Brain Organoid Models for Neurodegenerative Disease & Drug Discovery (HBOND) investigation studies 3D neuroglial organoids derived from the induced pluripotent stem cells (IPSCs) of patients with Parkinson’s disease and primary progressive multiple sclerosis. Results may improve understanding of neurodegenerative disease and accelerate the development of new treatments.

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jsc2024e021221 (2/21/2024) --- Precursor cells are shown from the Human Brain Organoid Models for Neurodegenerative Disease & Drug Discovery (HBOND) investigation of Parkinson’s disease. These Cosmic Brain Organoids will spend approximately 30 days on the International Space Station. This investigation studies 3D neuroglial organoids derived from the induced pluripotent stem cells (IPSCs) of patients with Parkinson’s disease and primary progressive multiple sclerosis. Results may improve understanding of neurodegenerative disease and accelerate the development of new treatments. Image courtesy of the New York Stem Cell Research Institute.

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iss071e019819 (April 22, 2024) --- Expedition 71 Flight Engineer and NASA astronaut Mike Barratt processes brain organoid samples inside the Life Science Glovebox for a neurodegenerative disorder study. Doctors will use the results from the investigation to learn how protect a crew member’s central nervous system and provide treatments for neurodegenerative conditions on Earth. The Human Brain Organoid Models for Neurodegenerative Disease & Drug Discovery (HBOND) investigation studies 3D neuroglial organoids derived from the induced pluripotent stem cells (IPSCs) of patients with Parkinson’s disease and primary progressive multiple sclerosis. Results may improve understanding of neurodegenerative disease and accelerate the development of new treatments.