![The stimulus of gravity affects RNA production, which helps maintain the strength of human muscles on Earth (top), as seen in this section of muscle fiber taken from an astronaut before spaceflight. Astronauts in orbit and patients on Earth fighting muscle-wasting diseases need countermeasures to prevent muscle atrophy, indicated here with white lipid droplets (bottom) in the muscle sample taken from the same astronaut after spaceflight. Kerneth Baldwin of the University of California, Irvine, is conducting research on how reducing the stimulus of gravity affects production of the RNA that the body uses as a blueprint for making muscle proteins. Muscle proteins are what give muscles their strength, so when the RNA blueprints aren't available for producing new proteins to replace old ones -- a situation that occurs in microgravity -- the muscles atrophy. When the skeletal muscle system is exposed to microgravity during spaceflight, the muscles undergo a reduced mass that translates to a reduction in strength. When this happens, muscle endurance decreases and the muscles are more prone to injury, so individuals could have problems in performing extravehicular activity [space walks] or emergency egress because their bodies are functionally compromised.](https://images-assets.nasa.gov/image/0300206/0300206~medium.jpg)
The stimulus of gravity affects RNA production, which helps maintain the strength of human muscles on Earth (top), as seen in this section of muscle fiber taken from an astronaut before spaceflight. Astronauts in orbit and patients on Earth fighting muscle-wasting diseases need countermeasures to prevent muscle atrophy, indicated here with white lipid droplets (bottom) in the muscle sample taken from the same astronaut after spaceflight. Kerneth Baldwin of the University of California, Irvine, is conducting research on how reducing the stimulus of gravity affects production of the RNA that the body uses as a blueprint for making muscle proteins. Muscle proteins are what give muscles their strength, so when the RNA blueprints aren't available for producing new proteins to replace old ones -- a situation that occurs in microgravity -- the muscles atrophy. When the skeletal muscle system is exposed to microgravity during spaceflight, the muscles undergo a reduced mass that translates to a reduction in strength. When this happens, muscle endurance decreases and the muscles are more prone to injury, so individuals could have problems in performing extravehicular activity [space walks] or emergency egress because their bodies are functionally compromised.
This is a wide-angle view of the Orbital Workshop lower level experiment area. In center foreground is the ergometer bicycle. In center background is a litter chair for the Human Vestibular Function experiment (Skylab Experiment M131) and in right background is the Lower Body Negative Pressure System experiment (Skylab Experiment M092). The ergometer bicycle was used for metabolic activity experiments and exercise. The purpose of the Human Vestibular (irner ear) Function experiment was to examine the effect of weightlessness on man's sensitivity and susceptibility to motion rotation, and his perception of orientation. The Lower Body Negative Pressure experiment investigated the relationship between the zero gravity environment and cardiovascular deconditioning. A characteristic of cardiovascular deconditoning is the partial failure of the blood vessels resulting in the excessive pooling of the blood in the legs when a person assumes an erect posture in a gravity field. The Marshall Space Flight Center had the program management responsibility for the development of Skylab hardware and experiments.
iss034e061633 (3/6/2013) --- Cosmonaut Evgeny Tarelkin, Flight Engineer (FE) conducting Sprut-2 Experiment run, in the Service Module (SM) aboard the International Space Station (ISS). The Study of Changes in Body Composition and Distribution of Fluids Within the Human Body During Long-term Spaceflight (Sprut-2) studies the change in body composition and fluid distribution in the human body during long-term spaceflight in order to evaluate adaptation mechanisms and improve countermeasures.
iss034e045766 (2/13/2013) --- Cosmonaut Evgeny Tarelkin, Expedition 34 Flight Engineer (FE), conducting SPRUT-2 Experiment, in the Service Module (SM) aboard the International Space Station (ISS). The Study of Changes in Body Composition and Distribution of Fluids Within the Human Body During Long-term Spaceflight (Sprut-2) studies the change in body composition and fluid distribution in the human body during long-term spaceflight in order to evaluate adaptation mechanisms and improve countermeasures.
This diagram shows the normal pathways of calcium movement in the body and indicates changes (green arrows) seen during preliminary space flight experiments. Calcium plays a central role because 1) it gives strength and structure to bone and 2) all types of cells require it to function normally. To better understand how and why weightlessness induces bone loss, astronauts have participated in a study of calcium kinetics -- that is, the movement of calcium through the body, including absorption from food, and its role in the formation and breakdown of bone.
Ann Hutchinson (as subject), Dr. Joan Vernikos (R), Dee O'Hara (L), J. Evans and E. Lowe pose for pictures in the NASA Magazine aritcle 'How it Feels to be a Human Test Subject' as they prepare for a bed rest study to simulate the efects of microgravity on the human body.
STS-90 Mission Specialist Richard Linnehan, D.V.M., sits in a chair during suitup activities in the Operations and Checkout Building. Linnehan and the rest of the STS-90 crew will shortly depart for Launch Pad 39B, where the Space Shuttle Columbia awaits a second liftoff attempt at 2:19 p.m. EDT. His second trip into space, Linnehan is participating in a life sciences research flight that will focus on the most complex and least understood part of the human body the nervous system. Neurolab will examine the effects of spaceflight on the brain, spinal cord, peripheral nerves and sensory organs in the human body
STS-90 Payload Specialist Jay Buckey, M.D., prepares for launch during suit-up activities in KSC's Operations and Checkout Building. Buckey and the rest of the STS-90 crew will shortly depart for Launch Pad 39B, where the Space Shuttle Columbia awaits a second liftoff attempt at 2:19 p.m. EDT. His first trip into space, Buckey is participating in a life sciences research flight that will focus on the most complex and least understood part of the human body the nervous system. Neurolab will examine the effects of spaceflight on the brain, spinal cord, peripheral nerves and sensory organs in the human body
STS-90 Mission Commander Richard Searfoss sits in a chair during suitup activities in the Operations and Checkout Building. Searfoss and the rest of his flight crew will shortly depart for Launch Pad 39B, where the Space Shuttle Columbia awaits a second liftoff attempt at 2:19 p.m. EDT. His third trip into space, Searfoss commands this life sciences research flight that will focus on the most complex and least understood part of the human body the nervous system. Neurolab will examine the effects of spaceflight on the brain, spinal cord, peripheral nerves and sensory organs in the human body
KENNEDY SPACE CENTER, FLA. -- STS-90 Mission Specialist Dafydd (Dave) Williams, M.D., with the Canadian Space Agency sits in a chair during suitup activities in the Operations and Checkout Building. Williams and the rest of the STS-90 crew will shortly depart for Launch Pad 39B, where the Space Shuttle Columbia awaits a second liftoff attempt at 2:19 p.m. EDT. His first trip into space, Williams is participating in this life sciences research flight that will focus on the most complex and least understood part of the human body the nervous system. Neurolab will examine the effects of spaceflight on the brain, spinal cord, peripheral nerves and sensory organs in the human body
KENNEDY SPACE CENTER, FLA. -- STS-90 Pilot Scott Altman is assisted during suit-up activities by Lockheed Suit Technician Valerie McNeil from Johnson Space Center in KSC's Operations and Checkout Building. Altman and the rest of the STS-90 crew will shortly depart for Launch Pad 39B, where the Space Shuttle Columbia awaits a second liftoff attempt at 2:19 p.m. EDT. His first trip into space, Altman is participating in a life sciences research flight that will focus on the most complex and least understood part of the human body the nervous system. Neurolab will examine the effects of spaceflight on the brain, spinal cord, peripheral nerves and sensory organs in the human body
KENNEDY SPACE CENTER, FLA. -- STS-90 Payload Specialist James Pawelczyk, Ph.D., stands ready for launch during suitup activities in the Operations and Checkout Building. Pawelczyk and the rest of the STS-90 crew will shortly depart for Launch Pad 39B, where the Space Shuttle Columbia awaits a second liftoff attempt at 2:19 p.m. EDT. His first trip into space, Pawelczyk is participating in this life sciences research flight that will focus on the most complex and least understood part of the human body the nervous system. Neurolab will examine the effects of spaceflight on the brain, spinal cord, peripheral nerves and sensory organs in the human body.
The human body contains more than 100,000 types of proteins, each providing information related to our health. Studying these proteins by crystallizing them helps researchers learn more about the body and potential disease treatments. Additionally, researchers have discovered that growing crystals in microgravity allows for slower growth and higher quality crystals. Hopkins and Glover both worked on the RTPCG-2 protein crystal experiment to advance new drug discoveries.
iss038e055233 (2/24/2014) --- Cosmonaut Oleg Kotov, Expedition 38 Commander, is seen during a Lower Body Negative Pressure (LBNP) exercise. This activity was performed for the DAN investigation where researchers revealed that crew members inadvertently hold their breath longer in microgravity than on the ground, especially if the crewmember is lying face up. A better understanding of the supply of oxygen to the body in microgravity allows researchers to provide the environment necessary for adequate intracellular functions and basic human health in space.
Marshall Porterfield, Life and Physical Sciences Division Director at NASA Headquarters, talks about the human body in microgravity and other life sciences at a NASA Social exploring science on the ISS at NASA Headquarters, Wednesday, Feb. 20, 2013 in Washington. Photo Credit: (NASA/Carla Cioffi)
iss066e098812 (12/30/2021) --- A view during installation of the Cytoskeleton experiment containers installed on the BIOLAB Rotor during Expedition 66. This investigation helps to understand the way in which the human body responds to microgravity, which could feed into the development of future countermeasures to help maintain an optimal level of crew member health and performance.
A NASA staff member shows attendees of the USA Science and Engineering Festival what happens to the human body in space without a space suit using a marshmallow bunny. The USA Science and Engineering Festival took place at the Washington Convention Center in Washington, DC on April 26 and 27, 2014. Photo Credit: (NASA/Aubrey Gemignani)
iss067e360110 (Sept. 13, 2022) --- NASA astronaut Bob Hines participates in the GRASP investigation to help researchers better understand if and how gravity acts as a reference for the control of reach-to-grasp movement. The information could provide further insight into the human body’s adaptation to the microgravity environment.
iss048e042371 (Jul. 21, 2016) --- Glove Box set up on the Kobairo Rack for the Mouse Epigenetics experiment in the Kibo Japanese Experiment Pressurized Module (JPM). The Mouse Epigenetics experiment studies the effects of the space environment on genetic activity, which can be used as a proxy for understanding how the human body changes in space.
iss042e021395 (12/5/2014) --- A view of Microbiome swab kit containing Microbiome samples from various physical surfaces prior to being stowed in MELFI or GLACIER. The Study of the Impact of Long-Term Space Travel on the Astronauts' Microbiome (Microbiome) experiment investigates the impact of space travel on both the human immune system and an individual’s microbiome (the collection of microbes that live in and on the human body at any given time).
iss060e015022 (7/28/2019) — NASA astronaut Nick Hague is shown holding the Perfect Crystals investigation samples within Styrofoam containers in Node 3 aboard the International Space Station (ISS). Growth of Large, Perfect Protein Crystals for Neutron Crystallography (Perfect Crystals) crystallizes human manganese superoxide dismutase in order to analyze its shape. This sheds light on how the antioxidant protein helps protect the human body from oxidizing radiation and oxides created as a byproduct of metabolism.
iss042e021398 (12/5/2014) --- A view of Microbiome swab kit containing Microbiome samples from various physical surfaces prior to being stowed in MELFI or GLACIER. The Study of the Impact of Long-Term Space Travel on the Astronauts' Microbiome (Microbiome) experiment investigates the impact of space travel on both the human immune system and an individual’s microbiome (the collection of microbes that live in and on the human body at any given time).
KENNEDY SPACE CENTER, FLA. -- STS-90 Mission Specialist Kathryn (Kay) Hire prepares for launch during suitup activities in the Operations and Checkout Building as Astronaut Support Personnel team member Heide Piper braids Hire's hair. Hire and the rest of the STS-90 crew will shortly depart for Launch Pad 39B, where the Space Shuttle Columbia awaits a second liftoff attempt at 2:19 p.m. EDT. Her first trip into space, Hire is participating in this life sciences research flight that will focus on the most complex and least understood part of the human body the nervous system. Neurolab will examine the effects of spaceflight on the brain, spinal cord, peripheral nerves and sensory organs in the human body.
KENNEDY SPACE CENTER, FLA. -- STS-90 Mission Specialist Dafydd (Dave) Williams, M.D., with the Canadian Space Agency speaks with friends and family members near Launch Pad 39B, from which he and the rest of the seven-member crew are scheduled to launch aboard Columbia on May 16 at 2:19 p.m. EDT. The astronauts are under strict health stabilization guidelines to protect them from close contact with persons who do not have health stabilization clearance. This is the 25th flight of Columbia and the 90th mission flown since the start of the Space Shuttle program. STS-90 is a nearly 17-day life sciences research flight that will focus on the most complex and least understood part of the human body the nervous system. Neurolab will examine the effects of spaceflight on the brain, spinal cord, peripheral nerves and sensory organs in the human body
KENNEDY SPACE CENTER, FLA. -- STS-90 Mission Specialist Kathryn (Kay) Hire waves to friends and family members near Launch Pad 39B, from which she and the rest of the seven-member crew are scheduled to launch aboard Columbia on May 16 at 2:19 p.m. EDT. The astronauts are under strict health stabilization guidelines to protect them from close contact with persons who do not have health stabilization clearance. This is the 25th flight of Columbia and the 90th mission flown since the start of the Space Shuttle program. STS-90 is a nearly 17-day life sciences research flight that will focus on the most complex and least understood part of the human body the nervous system. Neurolab will examine the effects of spaceflight on the brain, spinal cord, peripheral nerves and sensory organs in the human body
In this photograph, astronauts Owen Garriott on the body restriant system and Byron Lichtenberg prepare for a Vestibular Experiment during the Spacelab-1 mission. The Vestibular Experiments in Space were the study of the interaction among the otoliths, semicircular canals, vision, and spinal reflexes in humans. The main objective was to determine how the body, which receives redundant information for several sensory sources, interprets this information in microgravity. Another objective was to record and characterize the symptoms of space sickness experienced by crewmembers. The body restraint system was a rotating chair with a harness to hold the test subject in place. The crewmember wore an accelerometer and electrodes to record head motion and horizontal and vertical eye movement as the body rotated. The first Spacelab mission, Spacelab-1, sponsored jointly and shared equally by NASA and the European Space Agency, was a multidisciplinary mission; that is, investigations were performed in several different fields of scientific research. The overall goal of the mission was to verify Spacelab performance through a variety of scientific experiments. The Spacelab-1 was launched aboard the Space Shuttle Orbiter Columbia for the STS-9 mission on November 28, 1983. The Marshall Space Flight Center had management responsibilities for the mission.
Scientists at NASA's Marshall Space Flight Center in Huntsville, Alabama, clean equipment and prepare for shipment of the ring sheared drop payload currently set for launch on Northrop Grumman 16 the first week in August, 2021. The payload studies the formation of potentially destructive amyloid fibrils, or protein clusters, like those found in the brain tissue of patients battling neurodegenerative diseases. Such illnesses may damage neurons, the drivers of the human nervous system. Experimentation in microgravity provides the opportunity to study amyloid fibril formation in conditions more analogous to those found in the human body than can be studied in a ground-based laboratory environment.
Scientists at NASA's Marshall Space Flight Center in Huntsville, Alabama, clean equipment and prepare for shipment of the ring sheared drop payload currently set for launch on Northrop Grumman 16 the first week in August, 2021. The payload studies the formation of potentially destructive amyloid fibrils, or protein clusters, like those found in the brain tissue of patients battling neurodegenerative diseases. Such illnesses may damage neurons, the drivers of the human nervous system. Experimentation in microgravity provides the opportunity to study amyloid fibril formation in conditions more analogous to those found in the human body than can be studied in a ground-based laboratory environment.
Orion / Space Launch System: NASA has selected the design of a new Space Launch System SLS that will take the agency's astronauts farther into space than ever before and provide the cornerstone for America's future human space exploration efforts. The SLS will launch human crews beyond low Earth orbit in the Orion Multi-Purpose Crew Vehicle. Orion is America’s next generation spacecraft. It will serve as the exploration vehicle that will provide emergency abort capability, sustain the crew during space travel, carry the crew to distant planetary bodies, and provide safe return from deep space. Poster designed by Kennedy Space Center Graphics Department/Greg Lee. Credit: NASA
Scientists at NASA's Marshall Space Flight Center in Huntsville, Alabama, clean equipment and prepare for shipment of the ring sheared drop payload currently set for launch on Northrop Grumman 16 the first week in August, 2021. The payload studies the formation of potentially destructive amyloid fibrils, or protein clusters, like those found in the brain tissue of patients battling neurodegenerative diseases. Such illnesses may damage neurons, the drivers of the human nervous system. Experimentation in microgravity provides the opportunity to study amyloid fibril formation in conditions more analogous to those found in the human body than can be studied in a ground-based laboratory environment.
Ever since humans first saw birds soar through the sky, they have wanted to fly. The ancient Greeks and Romans pictured many of their gods with winged feet, and imagined mythological winged animals. According to the legend of Daedalus and Icarus, the father and son escaped prison by attaching wings made of wax and feathers to their bodies. Unfortunately, Icarus flew too near the sun, and the heat caused the wax and feathers to melt. The feathers fell off, and Icarus plummeted to the sea. Daedalus landed safely in Sicily.
iss051e044502 (5/17/2017) --- Crew members on the International Space Station completed a new session of the Genes in Space 2 investigation. Spaceflight causes many changes to the human body, including alterations in DNA and a weakened immune system. This study uses a new technology to study DNA in space to try and safeguard crew health. Credits: NASA
iss051e044497 (5/17/2017) --- Crew members on the International Space Station completed a new session of the Genes in Space 2 investigation. Spaceflight causes many changes to the human body, including alterations in DNA and a weakened immune system. This study uses a new technology to study DNA in space to try and safeguard crew health. Credits: NASA
iss030e033236 (12/24/2012) --- Top-open view of European Space Agency (ESA) Role of Apoptosis in Lymphocyte Depression 2 (ROALD-2) experiment in the KUBIK-3 thermostatic container, in the Columbus Module aboard the International Space Station (ISS). Role of the Endocannabinoid System in human Lymphocytes Exposed to Microgravity (ROALD2) investigates the function of endocannabinoids, substances produced within the body to activate cell membrane receptors, in the regulation of the immune processes and cell cycle under microgravity conditions.
iss060e073417 (Sept. 19, 2019) --- NASA astronauts Christina Koch and Nick Hague are pictured inside the U.S. Destiny laboratory module. Hague was setting up the Microgravity Sciences Glovebox to begin operations for the Ring-Sheared Drop experiment to understand how fluids flow in the human body and other materials. Koch had finished an exercise session after jogging on the COLBERT (Combined Operational Load Bearing External Resistance Treadmill).
Marshall Porterfield, Life and Physical Sciences Division Director at NASA Headquarters, talks about the human body in microgravity and other life sciences at a NASA Social exploring science on the ISS at NASA Headquarters, Wednesday, Feb. 20, 2013 in Washington. In the foreground is pictured Veggie, a container used for growing plants on the ISS. Photo Credit: (NASA/Carla Cioffi)
ISS037-E-010721 (5 Oct. 2013) --- A specimen of human blood or a body fluid like saliva and urine is stowed by astronaut Michael Hopkins onboard the International Space Station on Oct. 5, 2013. The objects of post-mission research by scientists on the ground, all the various aforementioned biological samples have to be frozen until the return to Earth.
jsc2020e008566 (12/31/2013) --- Lockheed Martin engineer Robert Benzio conducts a fit check with two Rodent Research modules at NASA's Ames Research Center in Moffett Field, California. The Rodent Research Facility provides rodent housing on board the International Space Station (ISS). Animal research is essential for understanding the impacts of spaceflight on the systems of the human body, and for development of potential therapies that will ease harmful responses to space flight. Credits: NASA/Dominic Hart
Within five days, bioreactor cultivated human colon cancer cells (shown) grown in Microgravity on the STS-70 mission in 1995, had grown 30 times the volume of the control specimens on Earth. The samples grown in space had a higher level of cellular organization and specialization. Because they more closely resemble tumors found in the body, microgravity grown cell cultures are ideal for research purposes.
iss051e029016 (4/28/2017) --- Crew members on the International Space Station completed a new session of the Genes in Space 2 investigation. Spaceflight causes many changes to the human body, including alterations in DNA and a weakened immune system. This study uses a new technology to study DNA in space to try and safeguard crew health. Credits: NASA
jsc2020e008565 (12/27/2013) --- NASA’s Rodent Habitat module with both access doors open. The Rodent Research Facility provides rodent housing on board the International Space Station (ISS). Animal research is essential for understanding the impacts of spaceflight on the systems of the human body, and for development of potential therapies that will ease harmful responses to space flight. Credits: NASA/Dominic Hart
iss071e113128 (May 22, 2024) --- Expedition 71 Flight Engineer and NASA astronaut Matthew Dominick works in the International Space Station's Columbus laboratory module performing maintenance on the Space Linear Acceleration Mass Measurement Device, or SLAMMD. The human research device applies a known force to a crew member then calculates body mass using a form of Newton’s Second Law of Motion, force equals mass times acceleration.
iss073e0384171 (July 1, 2025) --- Expedition 73 Flight Engineer Jonny Kim (right) of NASA draws a blood sample from station Commander Takuya Onishi of JAXA (Japan Aerospace Exploration Agency) for processing in a centrifuge and preservation in a science freezer. The samples will be returned to Earth where scientists will analyze the specimens to learn how living and working in microgravity affects the human body and provide countermeasures to potential space-caused symptoms.
iss073e0511718 (Aug. 20, 2025) --- NASA astronaut and Expedition 73 Flight Engineer Zena Cardman speaks on a ham radio with the NixderStelar youth organization from Lima, Peru. The youngsters asked about using artificial intelligence on the International Space Station, how research in space benefits humans on Earth, and how living in weightlessness affects their bodies. Astronauts frequently speak to students, professionals, and government officials using the ham radio aboard the orbital outpost's Destiny laboratory module.
ISS002-E-6080 (2 May 2001) --- The Phantom Torso, seen here in the Human Research Facility (HRF) section of the Destiny/U.S. laboratory on the International Space Station (ISS), is designed to measure the effects of radiation on organs inside the body by using a torso that is similar to those used to train radiologists on Earth. The torso is equivalent in height and weight to an average adult male. It contains radiation detectors that will measure, in real-time, how much radiation the brain, thyroid, stomach, colon, and heart and lung area receive on a daily basis. The data will be used to determine how the body reacts to and shields its internal organs from radiation, which will be important for longer duration space flights. The experiment was delivered to the orbiting outpost during by the STS-100/6A crew in April 2001. Dr. Gautam Badhwar, NASA JSC, Houston, TX, is the principal investigator for this experiment. A digital still camera was used to record this image.
Proteins are the building blocks of our bodies and the living world around us. Within our bodies proteins make it possible for red blood cells to carry oxygen throughout the body. Others help transmit nerve impulses so we can hear, smell and feel the world around us. While others play a crucial role in preventing or causing disease. If the structure of a protein is known, then companies can develop new or improved drugs to fight the disease of which the protein is a part. To determine protein structure, researchers must grow near-perfect crystals of the protein. On Earth convection currents, sedimentation and other gravity-induced phenomena hamper crystal growth efforts. In microgravity researchers can grow near-perfect crystals in an environment free of these effects. Because of the enormous potential for new pharmaceutical products the Center for Macromolecular Crystallography--the NASA Commercial Space Center responsible for commercial protein crystal growth efforts has more than fifty major industry and academic partners. Research on crystals of human insulin could lead to improved treatments for diabetes.
KENNEDY SPACE CENTER, FLA. -- The STS-90 crew wave to friends and family members near Launch Pad 39B, from which they are scheduled to launch aboard Columbia on May 16 at 2:19 p.m. EDT. The crew include, left to right, Mission Specialist Richard Linnehan, D.V.M., Commander Richard Searfoss, Pilot Scott Altman, Payload Specialists James Pawelczyk, Ph.D., and Jay Buckey, M.D., and Mission Specialists Dafydd (Dave) Williams, M.D., with the Canadian Space Agency, and Kathryn (Kay) Hire. The Space Shuttle Columbia is seen in the background, protected by its Rotating Service Structure. This is the 25th flight of Columbia and the 90th mission flown since the start of the Space Shuttle program. STS-90 is a nearly 17-day life sciences research flight that will focus on the most complex and least understood part of the human body the nervous system. Neurolab will examine the effects of spaceflight on the brain, spinal cord, peripheral nerves and sensory organs in the human body
Astronaut Chiaki Mukai conducts the Lower Body Negative Pressure (LBNP) experiment inside the International Microgravity Laboratory-2 (IML-2) mission science module. Dr. Chiaki Mukai is one of the National Space Development Agency of Japan (NASDA) astronauts chosen by NASA as a payload specialist (PS). She was the second NASDA PS who flew aboard the Space Shuttle, and was the first female astronaut in Asia. When humans go into space, the lack of gravity causes many changes in the body. One change is that fluids normally kept in the lower body by gravity shift upward to the head and chest. This is why astronauts' faces appear chubby or puffy. The change in fluid volume also affects the heart. The reduced fluid volume means that there is less blood to circulate through the body. Crewmembers may experience reduced blood flow to the brain when returning to Earth. This leads to fainting or near-fainting episodes. With the use of the LBNP to simulate the pull of gravity in conjunction with fluids, salt tablets can recondition the cardiovascular system. This treatment, called "soak," is effective up to 24 hours. The LBNP uses a three-layer collapsible cylinder that seals around the crewmember's waist which simulates the effects of gravity and helps pull fluids into the lower body. The data collected will be analyzed to determine physiological changes in the crewmembers and effectiveness of the treatment. The IML-2 was the second in a series of Spacelab flights designed by the international science community to conduct research in a microgravity environment Managed by the Marshall Space Flight Center, the IML-2 was launched on July 8, 1994 aboard the STS-65 Space Shuttle Orbiter Columbia mission.
The first United States Microgravity Laboratory (USML-1) flew in orbit inside the Spacelab science module for extended periods, providing scientists and researchers greater opportunities for research in materials science, fluid dynamics, biotechnology (crystal growth), and combustion science. In this photograph, Astronaut Bornie Dunbar and Astronaut Larry DeLucas are conducting the Lower Body Negative Pressure (LBNP) experiment, which is to protect the health and safety of the crew and to shorten the time required to readapt to gravity when they return to Earth. When humans go into space, the lack of gravity causes many changes in the body. One change is that fluids normally kept in the lower body by gravity, shift upward to the head and chest. This is why astronauts' faces appear chubby or puffy. The change in fluid volume also affects the heart. The reduced fluid volume means that there is less blood to circulate through the body. Crewmembers may experience reduced blood flow to the brain when returning to Earth. This leads to fainting or near-fainting episodes. With the use of LBNP to simulate the pull of gravity in conjunction with fluids, salt tablets can recondition the cardiovascular system. This treatment, called "soak," is effective up to 24 hours. The LBNP uses a three-layer collapsible cylinder that seals around the crewmember's waist which simulates the effects of gravity and helps pull fluids into the lower body. The data collected will be analyzed to determine physiological changes in the crewmembers and effectiveness of the treatment. The USML-1 was launched aboard the Space Shuttle Orbiter Columbia (STS-50) on June 25, 1992.
ISS043E059259 (03/28/2015) --- NASA astronaut Scott Kelly (left) is happy to be aboard the International Space Station after the hatch opening of the Soyuz spacecraft Mar. 28, 2015. Kelly traveled with Expedition 43 Russian cosmonauts Mikhail Kornienko and Gennady Padalka of the Russian Federal Space Agency (Roscosmos) on the Soyuz TMA-16M that launched Friday, March 27, 2015 from Baikonur, Kazakhstan. Kelly and Kornienko will spend a year in space and return to Earth on Soyuz TMA-18M in March 2016. Most expeditions to the space station last four to six months. By doubling the length of this mission, researchers hope to better understand how the human body reacts and adapts to long-duration spaceflight. This knowledge is critical as NASA looks toward human journeys deeper into the solar system, including to and from Mars.
KENNEDY SPACE CENTER, FLA. - The Space Shuttle Columbia climbs a golden tower into a royal blue sky dusted with clouds. The 58th Shuttle flight lifted off from Launch Pad 39B at 10:53:10 a.m. EDT, beginning the longest mission planned in Shuttle program history: two weeks. The Extended Duration Orbiter STS-58 mission will allow the seven-member crew to delve extensively into a number of experiments investigating the adaptation of the human body to space. Spacelab Llife Sciences-2 is the second Spacelab mission dedicated solely to life sciences research.
S73-20695 (1 March 1973) --- Astronaut Charles Conrad Jr., commander of the first manned Skylab mission, checks out the Human Vestibular Function, Experiment M131, during Skylab training at Johnson Space Center. Conrad is in the work and experiments compartment of the crew quarters of the Skylab Orbital Workshop (OWS) trainer at JSC. The reference sphere with a magnetic rod is used by the astronaut to indicate body orientation non-visually. The litter chair in which he is seated can be rotated by a motor at its base or, when not being rotated, can tilt forward, backward or to either side. Photo credit: NASA
STS-90 Payload Specialist James Pawelczyk, Ph.D., stands behind his two children, Bradley and Katlyn (left to right), as they smile to photographers near Launch Pad 39B. James and the rest of the seven-member crew are scheduled to launch aboard Columbia, seen in the background, on May 16 at 2:19 p.m. EDT. The astronauts are under strict health stabilization guidelines to protect them from close contact with persons who do not have health stabilization clearance. This is the 25th flight of Columbia and the 90th mission flown since the start of the Space Shuttle program. This launch of Neurolab will examine the effects of spaceflight on the brain, spinal cord, peripheral nerves and sensory organs in the human body
iss052e018939 (7/24/2017) --- NASA astronaut Peggy Whitson working with the Efficacy and Metabolism of Azonafide Antibody-Drug Conjugates in Microgravity (ADCs in Microgravity). The ADCs in Microgravity investigation evaluates new antibody-drug conjugates that combine an immune-activating drug with antibodies in order to target only cancer cells, increasing the effectiveness of chemotherapy and reducing its side effects. In microgravity, cancer cells grow in three-dimensional, spheroid structures that closely resemble their form in the human body, allowing for better drug testing. This investigation may accelerate development of targeted therapies for cancer patients.
jsc2024e038399 (6/5/2024) --- Glycine crystals grown with Redwire's PIL-BOX aboard the International Space Station. This image was taken after the crystals returned to Earth in April 2024. Glycine is an amino acid which serves many functions in the human body such as a neurotransmitter, a component in collagen, and a building block for other important molecules. The Pharmaceutical In-space Laboratory-03 (ADSEP-PIL-03) investigation grows crystals of several commercially relevant small molecules, each having various structures that may be altered by a microgravity environment. Image courtesy of Redwire.
Pictured is an artist's concept of the International Space Station (ISS) with solar panels fully deployed. In addition to the use of solar energy, the ISS will employ at least three types of propulsive support systems for its operation. The first type is to reboost the Station to correct orbital altitude to offset the effects of atmospheric and other drag forces. The second function is to maneuver the ISS to avoid collision with oribting bodies (space junk). The third is for attitude control to position the Station in the proper attitude for various experiments, temperature control, reboost, etc. The ISS, a gateway to permanent human presence in space, is a multidisciplinary laboratory, technology test bed, and observatory that will provide an unprecedented undertaking in scientific, technological, and international experimentation by cooperation of sixteen countries.
ISS006-E-50419 (2003) --- This digital still camera image of Cape Hatteras and Cape Lookout, North Carolina, with a Soyuz vehicle docked to the orbital outpost in the foreground was taken by Expedition 6 crewmember Don Pettit during his 5 1/2 month stay on the International Space Station (ISS). The largest inland body of water is Pamlico Sound. Kitty Hawk, on North Carolina's Outer Banks is also visible. On Dec. 17, 2003, the world celebrates a century of human flight with the anniversary of the Wright Brothers' first flight at Kitty Hawk. The brothers used the Outer Banks' prevailing winds and a 90-foot hill (Kill Devil Hill) to successfully demonstrate powered flight.
iss052e018944 (7/24/2017) --- NASA astronaut Peggy Whitson working with the Efficacy and Metabolism of Azonafide Antibody-Drug Conjugates in Microgravity (ADCs in Microgravity). The ADCs in Microgravity investigation evaluates new antibody-drug conjugates that combine an immune-activating drug with antibodies in order to target only cancer cells, increasing the effectiveness of chemotherapy and reducing its side effects. In microgravity, cancer cells grow in three-dimensional, spheroid structures that closely resemble their form in the human body, allowing for better drug testing. This investigation may accelerate development of targeted therapies for cancer patients.
All this week, the THEMIS Image of the Day is following on the real Mars the path taken by fictional astronaut Mark Watney, stranded on the Red Planet in the book and movie, The Martian. Today's image shows a small portion of Acidalia Planitia, a largely flat plain that is part of Mars' vast northern lowlands. Scientists are debating the likelihood that the northern plains once contained a large ocean or other bodies of water, probably ice-covered. In the story, Acidalia Planitia is the landing site for a human expedition to Mars. After a dust storm damages the crew habitat and apparently kills Watney, the remaining crew abandon the expedition and leave for Earth. Watney however is still alive, and to save himself he must journey nearly 4,000 kilometers (2,500 miles) east to Schiaparelli Crater, where a rescue rocket awaits. Orbit Number: 27733 Latitude: 31.218 Longitude: 332.195 Instrument: VIS Captured: 2008-03-15 20:24 http://photojournal.jpl.nasa.gov/catalog/PIA19796
This photo shows Psyche's multispectral imager, in the process of assembly and testing on Sept. 13, 2021, at Malin Space Science Systems in San Diego, California. Psyche, set to launch in August 2022, will investigate a metal-rich asteroid of the same name, which lies in the main asteroid belt between Mars and Jupiter. Scientists believe the asteroid could be part or all of the iron-rich interior of an early planetary building block that was stripped of its outer rocky shell as it repeatedly collided with other large bodies during the early formation of the solar system. The multispectral imager is sensitive to visible light like we can see with our eyes, but also to light just beyond what humans can see, using filters in the ultraviolet and near-infrared wavelengths. The photos taken in these filters will reveal the asteroid's geology and topography, and could help determine the mineralogy of any rocky material that may exist on the surface of Psyche. https://photojournal.jpl.nasa.gov/catalog/PIA24894
KENNEDY SPACE CENTER, Fla. - A small herd of wild pigs root for food along the bank of this body of water at Kennedy Space Center. Not a native in the environment, the pigs are believed to be descendants from those brought to Florida by the early Spanish explorers. Without many predators other than human, the pigs have flourished in the surrounding environs, primarily the Merritt Island National Wildlife Refuge, which shares a boundary with the Center. The Wildlife Refuge encompasses 92,000 acres that are a habitat for more than 331 species of birds, 31 mammals, 117 fishes, and 65 amphibians and reptiles. The marshes and open water of the refuge provide wintering areas for 23 species of migratory waterfowl, as well as a year-round home for great blue herons, great egrets, wood storks, cormorants, brown pelicans and other species of marsh and shore birds, plus a variety of insects.
This is a von Braun 1952 space station concept. In a 1952 series of articles written in Collier's, Dr. Wernher von Braun, then Technical Director of the Army Ordnance Guided Missiles Development Group at Redstone Arsenal, wrote of a large wheel-like space station in a 1,075-mile orbit. This station, made of flexible nylon, would be carried into space by a fully reusable three-stage launch vehicle. Once in space, the station's collapsible nylon body would be inflated much like an automobile tire. The 250-foot-wide wheel would rotate to provide artificial gravity, an important consideration at the time because little was known about the effects of prolonged zero-gravity on humans. Von Braun's wheel was slated for a number of important missions: a way station for space exploration, a meteorological observatory and a navigation aid. This concept was illustrated by artist Chesley Bonestell.
STS-40 Payload Specialist Millie Hughes-Fulford along with backup payload specialist Robert Ward Phillips familiarize themselves with Spacelab Life Sciences 1 (SLS-1) equipment. The two scientists are in JSC's Life Sciences Project Division (LSPD) SLS mockup located in the Bioengineering and Test Support Facility Bldg 36. Hughes-Fulford, in the center aisle, pulls equipment from an overhead stowage locker while Phillips, in the foreground, experiments with the baroreflex neck pressure chamber at Rack 11. The baroreflex collar will be used in conjuction with Experiment No. 022, Influence of Weightlessness Upon Human Autonomic Cardiovascular Control. Behind Phillips in the center aisle are body mass measurement device (BMMD) (foreground) and the stowed bicycle ergometer.
EDWARDS, Calif. – ED13-0142-11: The truck and trailer that transported the Dream Chaser engineering test article from Sierra Nevada Corporation, or SNC, Space Systems facility in Louisville, Colo., arrives on the aircraft ramp at NASA's Dryden Flight Research Center on Edwards Air Force Base, Calif., early in the morning. Based on NASA's HL-20 lifting body design, the Dream Chaser will begin its approach-and-landing flight test program in collaboration with NASA's Commercial Crew Program this summer. SNC is one of three companies working with NASA's Commercial Crew Program, or CCP, during the agency's Commercial Crew Integrated Capability, or CCiCap, initiative, which is intended to lead to the availability of commercial human spaceflight services for government and commercial customers. To learn more about CCP and its industry partners, visit www.nasa.gov/commercialcrew. Image credit: NASA/Tom Tschida
A drag chute slows the space shuttle Columbia as it rolls to a perfect landing concluding NASA's longest mission at that time, STS-58, at the Ames-Dryden Flight Research Facility (later redesignated the Dryden Flight Research Center), Edwards, California, with a 8:06 a.m. (PST) touchdown 1 November 1993 on Edward's concrete runway 22. The planned 14 day mission, which began with a launch from Kennedy Space Center, Florida, at 7:53 a.m. (PDT), October 18, was the second spacelab flight dedicated to life sciences research. Seven Columbia crewmembers performed a series of experiments to gain more knowledge on how the human body adapts to the weightless environment of space. Crewmembers on this flight included: John Blaha, commander; Rick Searfoss, pilot; payload commander Rhea Seddon; mission specialists Bill MacArthur, David Wolf, and Shannon Lucid; and payload specialist Martin Fettman.
The NASA Bioreactor provides a low turbulence culture environment which promotes the formation of large, three-dimensional cell clusters. Due to their high level of cellular organization and specialization, samples constructed in the bioreactor more closely resemble the original tumor or tissue found in the body. NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues currently being cultured in rotating bioreactors by investigators
The Blue Ring Nebula is thought to be the product of two stars merging into one. The collision of the bodies ejected a cloud of hot debris into space. A disk of gas orbiting the larger star cut the cloud in half, creating two cones that are moving away from the star in opposite directions. The base of one cone is moving almost directly toward Earth, while the other is moving almost directly away. Magenta represents optical light from the shockwave at the front of the expanding debris cones, outlining the two cone bases at their widest points. Blue represents far-ultraviolet light (not visible to the human eye) and comes from gas behind the shockwave. As the gas expands and cools, it forms hydrogen molecules that interact with the interstellar medium and emit only far-ultraviolet light. These emissions are visible only where the cones overlap (as seen from Earth), forming the blue ring around the central star. Movie available at https://photojournal.jpl.nasa.gov/catalog/PIA23868
STS078-396-015 (20 June - 7 July 1996) --- Payload specialist Jean-Jacques Favier, representing the French Space Agency (CNES), prepares a sample for the Advanced Gradient Heating Facility (AGHF) while wearing instruments that measure upper body movement. The Torso Rotation Experiment (TRE) complements other vestibular studies that measure differences in the way human beings react physically to their surroundings in microgravity. This is a typical Life and Microgravity Spacelab (LMS-1) mission scene, with several experiments being performed. Astronaut Susan J. Helms, payload commander, assists Favier in the AGHF preparations. Astronaut Richard M. Linnehan (bottom right), mission specialist, tests his muscle response with the Handgrip Dynamometer. Astronaut Thomas T. (Tom) Henricks (far background), mission commander, offers assistance.
HAMPTON, Va. –A 10-inch long ceramic model of the Sierra Nevada Corporation, or SNC, Dream Chaser spacecraft is prepared for high-speed wind tunnel tests at NASA's Langley Research Center in Hampton, Va. The tests measure how much heat the winged vehicle would experience during ascent and re-entry through the atmosphere, including the spacecraft's lower- and upper-body flaps, elevons and a rudder. They're also helping the company obtain necessary data for the material selection and design of the spacecraft's thermal protection system. SNC is continuing the development of its Dream Chaser spacecraft under the agency's Commercial Crew Integrated Capability, or CCiCap, initiative, which is intended to lead to the availability of commercial human spaceflight services for government and commercial customers. To learn more about CCP and its industry partners, visit www.nasa.gov/commercialcrew. Image credit: NASA/David Bowman
HAMPTON, Va. –A 10-inch long ceramic model of the Sierra Nevada Corporation, or SNC, Dream Chaser spacecraft undergoes high-speed wind tunnel tests at NASA's Langley Research Center in Hampton, Va. The tests measure how much heat the winged vehicle would experience during ascent and re-entry through the atmosphere, including the spacecraft's lower- and upper-body flaps, elevons and a rudder. They're also helping the company obtain necessary data for the material selection and design of the spacecraft's thermal protection system. SNC is continuing the development of its Dream Chaser spacecraft under the agency's Commercial Crew Integrated Capability, or CCiCap, initiative, which is intended to lead to the availability of commercial human spaceflight services for government and commercial customers. To learn more about CCP and its industry partners, visit www.nasa.gov/commercialcrew. Image credit: NASA/David Bowman
This new image taken with NASA's Hubble Space Telescope (HST) is of the nearby dwarf galaxy NGC 1569. This galaxy is a hotbed of vigorous star birth activity which blows huge bubbles that riddle its main body. The bubble structure is sculpted by the galactic super-winds and outflows caused by a colossal input of energy from collective supernova explosions that are linked with a massive episode of star birth. The bubbles seen in this image are made of hydrogen gas that glows when hit by the fierce wind and radiation from hot young stars and is racked by supernova shocks. Its "star factories" are also manufacturing brilliant blue star clusters. NGC 1569 had a sudden onset of star birth about 25 million years ago, which subsided about the time the very earliest human ancestors appeared on Earth. The Marshall Space Flight Center had responsibility for the design, development, and construction of the HST.
HAMPTON, Va. –A 10-inch long ceramic model of the Sierra Nevada Corporation, or SNC, Dream Chaser spacecraft is prepared for high-speed wind tunnel tests at NASA's Langley Research Center in Hampton, Va. The tests measure how much heat the winged vehicle would experience during ascent and re-entry through the atmosphere, including the spacecraft's lower- and upper-body flaps, elevons and a rudder. They're also helping the company obtain necessary data for the material selection and design of the spacecraft's thermal protection system. SNC is continuing the development of its Dream Chaser spacecraft under the agency's Commercial Crew Integrated Capability, or CCiCap, initiative, which is intended to lead to the availability of commercial human spaceflight services for government and commercial customers. To learn more about CCP and its industry partners, visit www.nasa.gov/commercialcrew. Image credit: NASA/David Bowman
KENNEDY SPACE CENTER, Fla. - A lone wild pig travels the bank of a body of water near Kennedy Space Center. In the background is the 525-foot-high Vehicle Assembly Building. Not a native in the environment, the pigs are believed to be descendants from those brought to Florida by the early Spanish explorers. Without many predators other than human, the pigs have flourished in the surrounding environs, primarily the Merritt Island National Wildlife Refuge, which shares a boundary with the Center. The Wildlife Refuge encompasses 92,000 acres that are a habitat for more than 331 species of birds, 31 mammals, 117 fishes, and 65 amphibians and reptiles. The marshes and open water of the refuge provide wintering areas for 23 species of migratory waterfowl, as well as a year-round home for great blue herons, great egrets, wood storks, cormorants, brown pelicans and other species of marsh and shore birds, plus a variety of insects.
KENNEDY SPACE CENTER, FLA. -- The STS-90 flight crew enjoy the traditional pre-liftoff breakfast in the crew quarters of the Operations and Checkout Building. They are, from left, Payload Specialist Jay Buckey, M.D., Mission Specialist Dafydd (Dave) Williams, M.D., with the Canadian Space Agency, Pilot Scott Altman, Commander Richard Searfoss, Mission Specialist Kathryn (Kay) Hire, Mission Specialist Richard Linnehan, D.V.M., and Payload Specialist James Pawelczyk, Ph.D. After a weather briefing, the flight crew will be fitted with their launch and entry suits and depart for Launch Pad 39B. Once there, they will take their positions in the crew cabin of the Space Shuttle Columbia to await liftoff during a two-and-a-half-hour window that will open at 2:19 p.m. EDT, Apr. 17. STS-90 is the launch of Neurolab, a nearly 17-day mission to examine the effects of spaceflight on the brain, spinal cord, peripheral nerves and sensory organs in the human body
The NASA Bioreactor provides a low turbulence culture environment which promotes the formation of large, three-dimensional cell clusters. Due to their high level of cellular organization and specialization, samples constructed in the bioreactor more closely resemble the original tumor or tissue found in the body. NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues currently being cultured in rotating bioreactors by investigators.
HAMPTON, Va. –Engineers monitor high-speed wind tunnel testing of a 10-inch long ceramic model of the Sierra Nevada Corporation, or SNC, Dream Chaser spacecraft at NASA's Langley Research Center in Hampton, Va. The tests measure how much heat the winged vehicle would experience during ascent and re-entry through the atmosphere, including the spacecraft's lower- and upper-body flaps, elevons and a rudder. They're also helping the company obtain necessary data for the material selection and design of the spacecraft's thermal protection system. SNC is continuing the development of its Dream Chaser spacecraft under the agency's Commercial Crew Integrated Capability, or CCiCap, initiative, which is intended to lead to the availability of commercial human spaceflight services for government and commercial customers. To learn more about CCP and its industry partners, visit www.nasa.gov/commercialcrew. Image credit: NASA/David Bowman
HAMPTON, Va. –An engineer monitors high-speed wind tunnel testing of a 10-inch long ceramic model of the Sierra Nevada Corporation, or SNC, Dream Chaser spacecraft at NASA's Langley Research Center in Hampton, Va. The tests measure how much heat the winged vehicle would experience during ascent and re-entry through the atmosphere, including the spacecraft's lower- and upper-body flaps, elevons and a rudder. They're also helping the company obtain necessary data for the material selection and design of the spacecraft's thermal protection system. SNC is continuing the development of its Dream Chaser spacecraft under the agency's Commercial Crew Integrated Capability, or CCiCap, initiative, which is intended to lead to the availability of commercial human spaceflight services for government and commercial customers. To learn more about CCP and its industry partners, visit www.nasa.gov/commercialcrew. Image credit: NASA/David Bowman
Howard Hasbrook volunteers for a demonstration of a scaled-down version of Lieutenant Colonel John Stapp’s rocket sled set up in the hangar at the National Advisory Committee for Aeronautics (NACA) Lewis Flight Propulsion Laboratory. In 1945 Stapp, an Air Force medical doctor, volunteered to participate in a deceleration program to study the human body’s tolerance to aircraft crash forces. A 1500-pound sled powered by rockets was installed in 1947 on a section of railroad track in the California desert. Stapp participated in 29 experiments over the next seven years and broke land and deceleration records. These tests studied the effects of acceleration, G-force, deceleration, and wind blast on humans. Stapp suffered broken bones and retinal hemorrhages, but suffered no permanent damage. NACA Lewis was conducting a series of crash impact studies in the mid-1950s using dummies in actual aircraft. Irving Pinkel, the director of the program, and Stapp became friends through their mutual interest in this field. In April 1956 Stapp visited the Cleveland lab to give a talk to the local section of the American Rocket Society that discussed issues relating to the escape of pilots from the cockpit of supersonic jet aircraft. That same week, NACA Lewis’ Pinkel, Gerard Pesman, Merritt Preston, and Dugald Black received the annual Laura Taber Barbour Air Safety Award for their work on the Crash Fire Program. Black and Preston are visible in the crowd in this photograph.
ISS029-S-001 (23 March 2011) --- On the Expedition 29 patch, the International Space Station (ISS) is shown following the path of the historic 18th century explorer, Captain James Cook, and his ship, Endeavour. During Cook?s three main voyages, he explored and mapped major portions of the oceans and coastlines under the flight path of the ISS and added immeasurably to the body of knowledge of that time. As the ISS sails a stardust trail ? following the spirit of Endeavour sailing toward the dark unknown and new discoveries ? it enlightens Earth below. Through the centuries, the quest for new discoveries has been a significant element of the human character, inspiring us to endure hardships and separation to be part of a mission which is greater than any individual. A spokesman for the crew stated, ?The crew of Expedition 29 is proud to continue the journey in this greatest of all human endeavors.? The NASA insignia design for shuttle and space station flights is reserved for use by the astronauts and for other official use as the NASA Administrator may authorize. Public availability has been approved only in the form of illustrations by the various news media. When and if there is any change in this policy, which is not anticipated, it will be publicly announced. Photo credit: NASA or National Aeronautics and Space Administration
For 5 days on the STS-70 mission, a bioreactor cultivated human colon cancer cells, which grew to 30 times the volume of control specimens grown on Earth. This significant result was reproduced on STS-85 which grew mature structures that more closely match what are found in tumors in humans. Shown here, clusters of cells slowly spin inside a bioreactor. On Earth, the cells continually fall through the buffer medium and never hit bottom. In space, they are naturally suspended. Rotation ensures gentle stirring so waste is removed and fresh nutrient and oxygen are supplied. The NASA Bioreactor provides a low turbulence culture environment which promotes the formation of large, three-dimensional cell clusters. Due to their high level of cellular organization and specialization, samples constructed in the bioreactor more closely resemble the original tumor or tissue found in the body. The Bioreactor is rotated to provide gentle mixing of fresh and spent nutrient without inducing shear forces that would damage the cells. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators.
Astronaut David C. Hilmers conducts the Microgravity Vestibular Investigations (MVI) sitting in its rotator chair inside the IML-1 science module. When environmental conditions change so that the body receives new stimuli, the nervous system responds by interpreting the incoming sensory information differently. In space, the free-fall environment of an orbiting spacecraft requires that the body adapts to the virtual absence of gravity. Early in flights, crewmembers may feel disoriented or experience space motion sickness. MVI examined the effects of orbital flight on the human orientation system to obtain a better understanding of the mechanisms of adaptation to weightlessness. By provoking interactions among the vestibular, visual, and proprioceptive systems and then measuring the perceptual and sensorimotor reactions, scientists can study changes that are integral to the adaptive process. The IML-1 mission was the first in a series of Shuttle flights dedicated to fundamental materials and life sciences research with the international partners. The participating space agencies included: NASA, the 14-nation European Space Agency (ESA), the Canadian Space Agency (CSA), the French National Center of Space Studies (CNES), the German Space Agency and the German Aerospace Research Establishment (DAR/DLR), and the National Space Development Agency of Japan (NASDA). Both life and materials sciences benefited from the extended periods of microgravity available inside the Spacelab science module in the cargo bay of the Space Shuttle Orbiter. Managed by the Marshall Space Flight Center, IML-1 was launched on January 22, 1992 aboard the Space Shuttle Orbiter Discovery (STS-42 mission).
KENNEDY SPACE CENTER, FLA. -- Two USA employees, Tim Seymour (at left) and Danny Brown (at right), look at the network signal processor (NSP) that was responsible for postponement of the launch of STS-90 on Apr. 16. The Space Shuttle Columbia's liftoff from Launch Pad 39B was postponed 24 hours due to difficulty with NSP No. 2 on the orbiter. This device formats data and voice communications between the ground and the Space Shuttle. The unit, which is located in the orbiter's mid-deck, was removed and replaced on Apr. 16. Mission managers first noticed the problem at about 3 a.m. during normal communications systems activation prior to tanking operations. As a result, work to load the external tank with the cryogenic propellants did not begin and launch postponement was made official at about 8:15 a.m. STS-90 is slated to be the launch of Neurolab, a nearly 17-day mission to examine the effects of spaceflight on the brain, spinal cord, peripheral nerves and sensory organs in the human body.
NASA's Lunar Trailblazer mission approaches the Moon as it enters its science orbit in this artist's concept. The small satellite will orbit about 60 miles (100 kilometers) above the lunar surface, producing the best-yet maps of water on the Moon. Lunar Trailblazer will discover where the Moon's water is, what form it is in, and how it changes over time. Observations gathered during the spacecraft's two-year prime mission will contribute to the understanding of water cycles on airless bodies throughout the solar system while also supporting future human and robotic missions to the Moon by identifying where water is located. Lunar Trailblazer was a selection of NASA's SIMPLEx (Small Innovative Missions for Planetary Exploration), which provides opportunities for low-cost science spacecraft to ride-share with selected primary missions. To maintain the lower overall cost, SIMPLEx missions have a higher risk posture and lighter requirements for oversight and management. This higher risk acceptance allows NASA to test pioneering technologies, and the definition of success for these missions includes the lessons learned from more experimental endeavors. https://photojournal.jpl.nasa.gov/catalog/PIA26457
KENNEDY SPACE CENTER, FLA. -- With the Rotating Service Structure (RSS) rolled back, at left, the Space Shuttle Columbia is nearly ready for launch of STS-90. Rollback of the RSS is a major preflight milestone, typically occurring during the T-11-hour hold on L-1 (the day before launch). The scheduled launch of Columbia on Apr. 16 from Launch Pad 39B was postponed 24 hours due to difficulty with network signal processor No. 2 on the orbiter. This device formats data and voice communications between the ground and the Space Shuttle. The unit, which is located in the orbiter's mid-deck, will be removed and replaced. Prior to launch, one of the final steps will be to load the external tank with approximately 500,000 gallons of liquid hydrogen and liquid oxygen for fueling the orbiters three main engines. Tanking had not yet begun when the launch scheduled for Apr. 16 was scrubbed. STS-90 is slated to be the launch of Neurolab, a nearly 17-day mission to examine the effects of spaceflight on the brain, spinal cord, peripheral nerves and sensory organs in the human body
Biotechnology Refrigerator that preserves samples for use in (or after culturing in) the NASA Bioreactor. The unit is shown extracted from a middeck locker shell. The NASA Bioreactor provides a low turbulence culture environment which promotes the formation of large, three-dimensional cell clusters. The Bioreactor is rotated to provide gentle mixing of fresh and spent nutrient without inducing shear forces that would damage the cells. Due to their high level of cellular organization and specialization, samples constructed in the bioreactor more closely resemble the original tumor or tissue found in the body. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators.
CAPE CANAVERAL, Fla. -- Under the watchful eyes of the spacecraft technicians in the Payload Hazardous Servicing Facility at NASA's Kennedy Space Center in Florida, the robotic arm of the Mars Science Laboratory (MSL) rover, Curiosity, moves into place against the body of the spacecraft. The arm will hold and maneuver instruments that will help scientists analyze Martian rocks and soil. Much like a human arm, the robotic arm has flexibility through shoulder, elbow, and wrist joints that permit the arm to extend, bend, and angle precisely against rocks and soil to grind away layers, take microscopic images and analyze their elemental composition. At the end of the arm is a hand-like structure, the turret, for holding various tools that can spin through a 350-degree turning range. A United Launch Alliance Atlas V-541 configuration will be used to loft MSL into space. Curiosity’s 10 science instruments are designed to search for evidence on whether Mars has had environments favorable to microbial life, including chemical ingredients for life. The unique rover will use a laser to look inside rocks and release its gasses so that the rover’s spectrometer can analyze and send the data back to Earth. MSL is scheduled to launch Nov. 25 from Space Launch Complex 41 on Cape Canaveral Air Force Station in Florida. For more information, visit http://www.nasa.gov/msl. Photo credit: NASA/Charisse Nahser
Diagram depicts the importance of cell-cell communication as central to the understanding of cancer growth and progression, the focus of the NASA bioreactor demonstration system (BDS-05) investigation. Microgravity studies will allow us to unravel the signaling and communication between these cells with the host and potential development of therapies for the treatment of cancer metastasis. The NASA Bioreactor provides a low turbulence culture environment which promotes the formation of large, three-dimensional cell clusters. Due to their high level of cellular organization and specialization, samples constructed in the bioreactor more closely resemble the original tumor or tissue found in the body. The Bioreactor is rotated to provide gentle mixing of fresh and spent nutrient without inducing shear forces that would damage the cells. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators. Credit: Emory University.
ISS037-S-001 (August 2012) --- Leonardo da Vinci's Vitruvian Man, created some 525 years ago, as a blend of art and science and a symbol of the medical profession, is depicted amongst the orbits of a variety of satellites circling the Earth at great speed. Da Vinci's drawing, based on the proportions of man as described by the Roman architect Vitruvius, is often used as a symbol of symmetry of the human body and the universe as a whole. Almost perfect in symmetry as well, the International Space Station, with its solar wings spread out and illuminated by the first rays of dawn, is pictured as a mighty beacon arcing upwards across our night skies, the ultimate symbol of science and technology of our age. Six stars represent the six members of Expedition 37 crew, which includes two cosmonauts with a medical background, as well as a native of Da Vinci's Italy. The design for insignia for space station flights is reserved for use by the crew members and for other official use as the NASA Administrator may authorize. Public availability has been approved only in the form of illustrations by the various news media. When and if there is any change in this policy, which is not anticipated, it will be publicly announced.
CAPE CANAVERAL, Fla. -- Kennedy Space Center Director Bob Cabana, left, Mark Sirangelo, head of Sierra Nevada Space Systems (SNSS) of Sparks, Nev., and NASA Administrator Charlie Bolden pose for a photo after signing a Space Act Agreement that will offer the company technical capabilities from Kennedy's uniquely skilled work force. Kennedy will help Sierra Nevada with the ground operations support of its lifting body reusable spacecraft called "Dream Chaser," which resembles a smaller version of the space shuttle orbiter. The spacecraft would carry as many as seven astronauts to the space station. Through the new agreement, Kennedy's work force will use its experience of processing the shuttle fleet for 30 years to help Sierra Nevada define and execute Dream Chaser's launch preparations and post-landing activities. In 2010 and 2011, Sierra Nevada was awarded grants as part of the initiative to stimulate the private sector in developing and demonstrating human spaceflight capabilities for NASA's Commercial Crew Program. The goal of the program, which is based in Florida at Kennedy, is to facilitate the development of a U.S. commercial crew space transportation capability by achieving safe, reliable and cost-effective access to and from the space station and future low Earth orbit destinations. Photo credit: NASA/Jim Grossmann
Interior of a Biotechnology Refrigerator that preserves samples for use in (or after culturing in) the NASA Bioreactor. The unit is shown extracted from a middeck locker shell. The NASA Bioreactor provides a low turbulence culture environment which promotes the formation of large, three-dimensional cell clusters. The Bioreactor is rotated to provide gentle mixing of fresh and spent nutrient without inducing shear forces that would damage the cells. Due to their high level of cellular organization and specialization, samples constructed in the bioreactor more closely resemble the original tumor or tissue found in the body. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators.
Cells cultured on Earth (left) typically settle quickly on the bottom of culture vessels due to gravity. In microgravity (right), cells remain suspended and aggregate to form three-dimensional tissue. The NASA Bioreactor provides a low turbulence culture environment which promotes the formation of large, three-dimensional cell clusters. The Bioreactor is rotated to provide gentle mixing of fresh and spent nutrient without inducing shear forces that would damage the cells. Due to their high level of cellular organization and specialization, samples constructed in the bioreactor more closely resemble the original tumor or tissue found in the body. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators.
STS046-33-028 (4 Aug. 1992) --- With the possibility of an extravehicular activity (EVA) being added to the agenda, the two EVA-trained crew members begin their "pre-breathe" period on the space shuttle Atlantis' flight deck. Astronauts Jeffrey A. Hoffman (left), payload commander, and Franklin R. Chang-Diaz, mission specialist, reported to this station and began the "pre-breathe" process when problems developed during the extension of the Tethered Satellite System (TSS). When the human body is exposed to a sudden decrease in atmospheric pressure (for instance, from the 10.2 ppsi in the crew cabin to the 4.5 ppsi of the Extravehicular Mobility Unit (EMU) spacesuit), nitrogen traces in the bloodstream will expand. This expansion can create tiny bubbles and potential for the "bends". In order to lessen the effect, an astronaut must "pre-breathe" pure oxygen (the same pure oxygen that he will breathe in the suit) to help "purge" nitrogen from his/her bloodstream before exerting him/herself in the low-pressure environment of the suit. The "pre-breathe" exercise and the EVA turned out to be not needed as the TSS operations were resumed by remote operations.
Interior view of the gas supply for the NASA Bioreactor. The NASA Bioreactor provides a low turbulence culture environment which promotes the formation of large, three-dimensional cell clusters. The Bioreactor is rotated to provide gentle mixing of fresh and spent nutrient without inducing shear forces that would damage the cells. Due to their high level of cellular organization and specialization, samples constructed in the bioreactor more closely resemble the original tumor or tissue found in the body. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators.
CAPE CANAVERAL, Fla. -- Sierra Nevada Space Systems (SNSS) of Sparks, Nev., and NASA signed a Space Act Agreement that will offer the company technical capabilities from Kennedy's uniquely skilled work force. Kennedy will help Sierra Nevada with the ground operations support of its lifting body reusable spacecraft called "Dream Chaser." The spacecraft, seen here as a display, resembles a smaller version of the space shuttle orbiter. The spacecraft would carry as many as seven astronauts to the space station. Through the new agreement, Kennedy's work force will use its experience of processing the shuttle fleet for 30 years to help Sierra Nevada define and execute Dream Chaser's launch preparations and post-landing activities. In 2010 and 2011, Sierra Nevada was awarded grants as part of the initiative to stimulate the private sector in developing and demonstrating human spaceflight capabilities for NASA's Commercial Crew Program. The goal of the program, which is based in Florida at Kennedy, is to facilitate the development of a U.S. commercial crew space transportation capability by achieving safe, reliable and cost-effective access to and from the space station and future low Earth orbit destinations. Photo credit: NASA/Jim Grossmann
CAPE CANAVERAL, Fla. -- In the Payload Hazardous Servicing Facility at Kennedy Space Center in Florida, spacecraft technicians monitor the movement of the robotic arm of the Mars Science Laboratory (MSL) rover, Curiosity, as it is stowed against the body of the spacecraft. The arm will hold and maneuver instruments that will help scientists analyze Martian rocks and soil. Much like a human arm, the robotic arm has flexibility through shoulder, elbow, and wrist joints that permit the arm to extend, bend, and angle precisely against rocks and soil to grind away layers, take microscopic images and analyze their elemental composition. At the end of the arm is a hand-like structure, the turret, for holding various tools that can spin through a 350-degree turning range. A United Launch Alliance Atlas V-541 configuration will be used to loft MSL into space. Curiosity’s 10 science instruments are designed to search for evidence on whether Mars has had environments favorable to microbial life, including chemical ingredients for life. The unique rover will use a laser to look inside rocks and release its gasses so that the rover’s spectrometer can analyze and send the data back to Earth. MSL is scheduled to launch Nov. 25 from Space Launch Complex 41 on Cape Canaveral Air Force Station in Florida. For more information, visit http://www.nasa.gov/msl. Photo credit: NASA/Charisse Nahser
With the Rotating Service Structure (RSS) rolled back, at left, the Space Shuttle Columbia is nearly ready for launch of STS-90. Rollback of the RSS is a major preflight milestone, typically occurring during the T-11-hour hold on L-1 (the day before launch). The scheduled launch of Columbia on Apr. 16 from Launch Pad 39B was postponed 24 hours due to difficulty with network signal processor No. 2 on the orbiter. This device formats data and voice communications between the ground and the Space Shuttle. The unit, which is located in the orbiter's mid-deck, will be removed and replaced. Prior to launch, one of the final steps will be to load the external tank with approximately 500,000 gallons of liquid hydrogen and liquid oxygen for fueling the orbiters three main engines. Tanking had not yet begun when the launch scheduled for Apr. 16 was scrubbed. STS-90 is slated to be the launch of Neurolab, a nearly 17-day mission to examine the effects of spaceflight on the brain, spinal cord, peripheral nerves and sensory organs in the human body
The NASA Bioreactor provides a low turbulence culture environment which promotes the formation of large, three-dimensional cell clusters. Due to their high level of cellular organization and specialization, samples constructed in the bioreactor more closely resemble the original tumor or tissue found in the body. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators. Cell constructs grown in a rotating bioreactor on Earth (left) eventually become too large to stay suspended in the nutrient media. In the microgravity of orbit, the cells stay suspended. Rotation then is needed for gentle stirring to replenish the media around the cells.
This prostate cancer construct was grown during NASA-sponsored bioreactor studies on Earth. Cells are attached to a biodegradable plastic lattice that gives them a head start in growth. Prostate tumor cells are to be grown in a NASA-sponsored Bioreactor experiment aboard the STS-107 Research-1 mission in 2002. Dr. Leland Chung of the University of Virginia is the principal investigator. The NASA Bioreactor provides a low turbulence culture environment which promotes the formation of large, three-dimensional cell clusters. Due to their high level of cellular organization and specialization, samples constructed in the bioreactor more closely resemble the original tumor or tissue found in the body. The Bioreactor is rotated to provide gentle mixing of fresh and spent nutrient without inducing shear forces that would damage the cells. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators. Credit: NASA and the University of Virginia.
Laptop computer sits atop the Experiment Control Computer for a NASA Bioreactor. The flight crew can change operating conditions in the Bioreactor by using the graphical interface on the laptop. The NASA Bioreactor provides a low turbulence culture environment which promotes the formation of large, three-dimensional cell clusters. The Bioreactor is rotated to provide gentle mixing of fresh and spent nutrient without inducing shear forces that would damage the cells. Due to their high level of cellular organization and specialization, samples constructed in the bioreactor more closely resemble the original tumor or tissue found in the body. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators.
CAPE CANAVERAL, Fla. -- In the Payload Hazardous Servicing Facility at NASA's Kennedy Space Center in Florida, the robotic arm of the Mars Science Laboratory (MSL) rover, Curiosity, has been stowed against the body of the spacecraft. The arm will hold and maneuver instruments that will help scientists analyze Martian rocks and soil. Much like a human arm, the robotic arm has flexibility through shoulder, elbow, and wrist joints that permit the arm to extend, bend, and angle precisely against rocks and soil to grind away layers, take microscopic images and analyze their elemental composition. At the end of the arm is a hand-like structure, the turret, for holding various tools that can spin through a 350-degree turning range. A United Launch Alliance Atlas V-541 configuration will be used to loft MSL into space. Curiosity’s 10 science instruments are designed to search for evidence on whether Mars has had environments favorable to microbial life, including chemical ingredients for life. The unique rover will use a laser to look inside rocks and release its gasses so that the rover’s spectrometer can analyze and send the data back to Earth. MSL is scheduled to launch Nov. 25 from Space Launch Complex 41 on Cape Canaveral Air Force Station in Florida. For more information, visit http://www.nasa.gov/msl. Photo credit: NASA/Charisse Nahser